PDF(Pubmed)
Abstract：
The 2019 coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has posed a considerable challenge to global healthcare. Acute interstitial nephritis (AIN) post SARS-CoV-2 infection and vaccination has been reported, but its clinical features and pathogenesis remained unclear. We reviewed so far the largest 22 cases of AIN post SARS-CoV-2 infection and 36 cases of AIN following COVID-19 vaccination. The onset of AIN was mainly related to messenger RNA vaccines (52.8%). Apart from fever, proteinuria (45.5%) was the main manifestation of AIN post SARS-CoV-2 infection, left acute kidney injury (AKI, 63.9%) in patients post COVID-19 vaccination. The potential mechanism of vaccination induced AIN was conjugating vaccines with proteins to form a hapten, which activated dendritic cells and promoted a cascade immunological reaction leading to AIN.
摘要：
由严重急性呼吸道综合症冠状病毒2型（SARS-CoV-2）引起的2019年冠状病毒病（COVID-19）大流行对全球医疗保健构成了相当大的挑战。已报道SARS-CoV-2感染和疫苗接种后的急性间质性肾炎（AIN），但其临床特征和发病机制仍不清楚。我们回顾了迄今为止最大的22例SARS-CoV-2感染后的AIN和36例COVID-19疫苗接种后的AIN。AIN的发病主要与信使RNA疫苗有关(52.8%)。除了发烧,蛋白尿（45.5％）是SARS-CoV-2感染后AIN的主要表现，左急性肾损伤（AKI，63.9%）在COVID-19疫苗接种后的患者中。疫苗接种诱导AIN的潜在机制是将疫苗与蛋白质结合形成半抗原，激活树突状细胞并促进导致AIN的级联免疫反应。
