Abstract：
The Japanese government\'s 2013 suspension of its proactive recommendation for Human papillomavirus (HPV) vaccination resulted in low HPV vaccination coverage and was unique. However, data on awareness and knowledge of HPV vaccines in the general population was limited. Here, to investigate more recent awareness and knowledge of HPV vaccines by age, gender, and socioeconomic status, we used data from the INFORM Study 2020, a nationally representative cross-sectional survey of self-administered questionnaires with 1,998 Japanese individuals aged 20 to 59 years. We found that 47.5% of females and 21.0% of males had heard of HPV, and 33.6% of females and 16.8% of males had knowledge of HPV vaccine efficacy. After adjusting for potential confounders, females aged 50-54 years were more likely to be aware of HPV than females aged 20-24 (AOR, 2.02, 95%CI: 1.12-3.65). Females (AOR, 2.13, 95%CI: 1.48-3.07) and males (AOR, 1.64, 95%CI: 1.03-2.59) with higher education had more awareness than those with less education. Females with higher education had more knowledge about HPV vaccine efficacy than those with less education (AOR, 1.70; 95%CI: 1.16-2.50). We found a generally low level of awareness and knowledge about HPV vaccines in Japan, which might be attributable to the suspension of proactive recommendations. Additionally, we identified disparities in awareness and knowledge by age, gender, socioeconomic status, and health literacy. Enhancing HPV awareness and understanding of HPV vaccines and implementing targeted efforts for specific subpopulations within Japan after the resumption of proactive recommendation for HPV vaccines, are imperative.
摘要：
日本政府2013年暂停积极推荐人乳头瘤病毒（HPV）疫苗接种，导致HPV疫苗接种覆盖率低，是独一无二的。然而,普通人群对HPV疫苗的认知和知识的数据有限.这里,按年龄调查HPV疫苗的最新认识和知识，性别,和社会经济地位，我们使用了INFORM研究2020的数据,该研究是一项全国代表性的横断面调查,对1,998名20~59岁的日本人进行了问卷调查.我们发现47.5%的女性和21.0%的男性听说过HPV。33.6%的女性和16.8%的男性了解HPV疫苗的效力。在调整了潜在的混杂因素后，50-54岁的女性比20-24岁的女性更容易意识到HPV（AOR，2.02，95CI：1.12-3.65）。女性（AOR，2.13，95CI：1.48-3.07）和男性（AOR，1.64，95CI：1.03-2.59）受过高等教育的人比受过较少教育的人有更多的意识。受过高等教育的女性比受过教育较少的女性更了解HPV疫苗的功效（AOR，1.70；95CI：1.16-2.50）。我们发现日本对HPV疫苗的认识和知识普遍较低，这可能归因于主动建议的暂停。此外,我们发现了不同年龄的意识和知识的差异，性别,社会经济地位,和健康素养。在恢复对HPV疫苗的积极推荐后，加强对HPV疫苗的认识和了解，并在日本境内针对特定亚群开展有针对性的工作。是当务之急。
