Abstract：
Parasitic blood diseases (theileriosis, babesiosis, anaplasmosis, and trypanosomiasis) are common in regions where the distributions of the hosts, parasites, and vectors are convergent. They endanger animal production, and a few are also harmful to public health. The acute phase reaction (APR) is a complex, non-specific reaction that occurs in various events, including surgical trauma, infection, stress, inflammation, and neoplasia. To understand pathogenesis, we must study APR effects and acute phase proteins (APPs) alterations in naturally occurring and experimental infections. The elevation of haptoglobin (Hp), Serum amyloid A (SAA), and fibrinogen concentrations was markedly significant in bovine and ovine theileriosis. Hp, SAA, ceruloplasmin, and fibrinogen concentrations in anaplasmosis were dramatically elevated. A significant increase in SAA was observed in bovine babesiosis, while ovine babesiosis showed a significant rise in sialic acid levels. In cases of trypanosomiasis caused by T. vivax, there have been reports of elevated levels of Hp, complement C3, and antitrypsin. Improving our understanding of APR could result in more effective methods for diagnosis, treatment, control, and eradication of diseases. The article provides an overview of APPs alterations and other inflammation-related parameters (some cytokines, adenosine deaminase, and sialic acids) in parasitic blood diseases of ruminants.
摘要：
寄生虫性血液病(Theileriosis，babesiosis,无形体病,和锥虫病)在宿主分布的地区很常见，寄生虫,向量是收敛的。它们危及动物生产，还有一些对公众健康有害。急性期反应(APR)是一个复杂的,在各种事件中发生的非特异性反应，包括手术创伤,感染,压力，炎症,和瘤形成。为了了解发病机制，我们必须研究自然发生和实验性感染中的APR效应和急性期蛋白（APPs）变化。触珠蛋白（Hp）的升高，血清淀粉样蛋白A(SAA),纤维蛋白原浓度在牛和绵羊的Theileriosis中明显显着。HP,SAA,铜蓝蛋白,无形体病中的纤维蛋白原浓度急剧升高。在牛babesiosis中观察到SAA的显着增加，而绵羊巴贝斯虫病的唾液酸水平显着升高。在由间日疟原虫引起的锥虫病的病例中，有Hp水平升高的报道,补体C3和抗胰蛋白酶。提高我们对APR的理解可能会导致更有效的诊断方法，治疗,control,根除疾病。本文概述了APP改变和其他炎症相关参数(一些细胞因子，腺苷脱氨酶，和唾液酸）在反刍动物的寄生性血液疾病中。
