PDF(Pubmed)
Abstract：
Transoral laser microsurgery represents the primary surgical modality for early laryngeal cancers with oncologic outcomes equivalent to radiotherapy. Accurate tumor mapping and margin assessment can be difficult, however, particularly during piecemeal or ablative resections, and for tumors with a wider geographic footprint. Tumor-targeted fluorescence-guided surgery in patients with head and neck cancer has empirically improved tumor and margin identification; this case details, for the first time, a fluorescence-guided surgical resection of a T2N0M0 transglottic tumor using panitumumab-IRDye800, an epidermal growth factor receptor monoclonal antibody covalently linked to near-infrared (NIR) dye. Laryngoscope, 134:1837-1841, 2024.
摘要：
经口激光显微手术代表了早期喉癌的主要手术方式，其肿瘤学结果与放射疗法相当。准确的肿瘤标测和边缘评估可能很困难，然而,特别是在零碎或切除切除期间，以及具有更广泛地理足迹的肿瘤。头颈部肿瘤患者的肿瘤靶向荧光引导手术在经验上改善了肿瘤和边缘识别；这个病例细节，第一次,使用panitumumab-IRDye800,一种与近红外(NIR)染料共价连接的表皮生长因子受体单克隆抗体,在荧光引导下对T2N0M0跨声门型肿瘤进行手术切除.喉镜,2023年。
