PDF(Pubmed)
Abstract：
UNASSIGNED: Specific IgE (sIgE) is merely a sensitization marker that cannot be used for allergy diagnosis if there are no associated clinical symptoms. As of 2023, there is still no evidence regarding the quantity of sIgE necessary to confirm or exclude clinical disease. Therefore, this study aimed to calculate cut-offs for sIgE, allowing us to effectively diagnose olive or grass pollen allergy and select allergenic immunotherapy (AIT) candidate patients in a region under high olive and grass allergenic pressure.
UNASSIGNED: An observational retrospective study consisting of the review of electronic medical records from 1,172 patients diagnosed with seasonal rhino-conjunctivitis and suspected allergy to olive or grass pollen. Symptoms correlated with sIgE to Poaceae and Oleaceae whole extracts and sIgE to genuine allergenic components were evaluated. Optimal cut-off values were calculated using receiver operating characteristic curves. Relevant clinical symptoms and AIT indications were taken into consideration when determining the clinical allergy diagnosis.
UNASSIGNED: sIgE to Lolium showed the best area under the curve (AUC) for both diagnosis (0.957) and an indication of AIT (0.872). The optimal cut-off values for grass diagnosis and AIT indication were 1.79 kUA/L and 8.83 kUA/L, respectively. A value of 5.62 kUA/L was associated with a positive likelihood ratio (LR) of 10.08 set for grass allergy. Olea sIgE showed the best AUC for the diagnosis (0.950). The optimal cut-off for diagnosis was 2.41 kUA/L. A value of 6.49 kUA/L was associated with a positive LR of 9.98 to confirm olive pollen allergy. In regard to immunotherapy, Ole e 1 sIgE showed the best AUC (0.860). The optimal cut-off was 14.05 kUA/L. Ole e 1 sIgE value of 4.8 kUA/L was associated with a 0.09 negative LR to exclude olive AIT indication.
UNASSIGNED: The sIgE cut-offs found in this population under high olive and grass allergenic pressure reduce the gap between sensitization and clinical allergy, providing a new tool for the diagnosis of seasonal allergic rhinitis/asthma and helping to discriminate patients who will benefit from AIT.
UNASSIGNED: An observational retrospective study consisting of the review of electronic medical records from 1,172 patients diagnosed with seasonal rhino-conjunctivitis and suspected allergy to olive or grass pollen. Symptoms correlated with sIgE to Poaceae and Oleaceae whole extracts and sIgE to genuine allergenic components were evaluated. Optimal cut-off values were calculated using receiver operating characteristic curves. Relevant clinical symptoms and AIT indications were taken into consideration when determining the clinical allergy diagnosis.
UNASSIGNED: sIgE to Lolium showed the best area under the curve (AUC) for both diagnosis (0.957) and an indication of AIT (0.872). The optimal cut-off values for grass diagnosis and AIT indication were 1.79 kUA/L and 8.83 kUA/L, respectively. A value of 5.62 kUA/L was associated with a positive likelihood ratio (LR) of 10.08 set for grass allergy. Olea sIgE showed the best AUC for the diagnosis (0.950). The optimal cut-off for diagnosis was 2.41 kUA/L. A value of 6.49 kUA/L was associated with a positive LR of 9.98 to confirm olive pollen allergy. In regard to immunotherapy, Ole e 1 sIgE showed the best AUC (0.860). The optimal cut-off was 14.05 kUA/L. Ole e 1 sIgE value of 4.8 kUA/L was associated with a 0.09 negative LR to exclude olive AIT indication.
UNASSIGNED: The sIgE cut-offs found in this population under high olive and grass allergenic pressure reduce the gap between sensitization and clinical allergy, providing a new tool for the diagnosis of seasonal allergic rhinitis/asthma and helping to discriminate patients who will benefit from AIT.
摘要：
■特异性IgE(sIgE)仅仅是在没有相关临床症状的情况下不能用于过敏诊断的致敏标记物。截至2023年，仍然没有证据表明确认或排除临床疾病所需的sIgE数量。因此,这项研究旨在计算sIgE的截止值，使我们能够有效地诊断橄榄或草花粉过敏，并在高橄榄和草过敏压力的地区选择过敏免疫疗法（AIT）候选患者。
■一项观察性回顾性研究，包括1,172名被诊断为季节性犀牛结膜炎并怀疑对橄榄或草花粉过敏的患者的电子病历。评估了与禾本科和木脂科整体提取物的sIgE相关的症状以及与真正的致敏性成分的sIgE。使用接收器工作特性曲线计算最佳截止值。在确定临床过敏诊断时考虑了相关的临床症状和AIT指征。
■黑麦草的sIgE显示出诊断（0.957）和AIT指征（0.872）的最佳曲线下面积（AUC）。草诊断和AIT适应症的最佳临界值为1.79kUA/L和8.83kUA/L，分别。5.62kUA/L的值与草过敏的阳性似然比（LR）为10.08相关。OleasIgE显示出用于诊断的最佳AUC(0.950)。诊断的最佳截止值为2.41kUA/L。6.49kUA/L的值与9.98的阳性LR相关，以确认橄榄花粉过敏。关于免疫疗法，Olee1sIgE显示出最好的AUC(0.860)。最佳截止值为14.05kUA/L。4.8kUA/L的Olee1sIgE值与0.09阴性LR相关，以排除橄榄AIT指征。
■在高橄榄和草过敏压力下在该人群中发现的sIgE截止值减少了致敏和临床过敏之间的差距，为季节性过敏性鼻炎/哮喘的诊断提供了新的工具，并帮助区分将从AIT中受益的患者。
■一项观察性回顾性研究，包括1,172名被诊断为季节性犀牛结膜炎并怀疑对橄榄或草花粉过敏的患者的电子病历。评估了与禾本科和木脂科整体提取物的sIgE相关的症状以及与真正的致敏性成分的sIgE。使用接收器工作特性曲线计算最佳截止值。在确定临床过敏诊断时考虑了相关的临床症状和AIT指征。
■黑麦草的sIgE显示出诊断（0.957）和AIT指征（0.872）的最佳曲线下面积（AUC）。草诊断和AIT适应症的最佳临界值为1.79kUA/L和8.83kUA/L，分别。5.62kUA/L的值与草过敏的阳性似然比（LR）为10.08相关。OleasIgE显示出用于诊断的最佳AUC(0.950)。诊断的最佳截止值为2.41kUA/L。6.49kUA/L的值与9.98的阳性LR相关，以确认橄榄花粉过敏。关于免疫疗法，Olee1sIgE显示出最好的AUC(0.860)。最佳截止值为14.05kUA/L。4.8kUA/L的Olee1sIgE值与0.09阴性LR相关，以排除橄榄AIT指征。
■在高橄榄和草过敏压力下在该人群中发现的sIgE截止值减少了致敏和临床过敏之间的差距，为季节性过敏性鼻炎/哮喘的诊断提供了新的工具，并帮助区分将从AIT中受益的患者。
