PDF(Pubmed)
Abstract：
Following stimulation, the T cell receptor (TCR) and its coreceptors integrate multiple intracellular signals to initiate T cell proliferation, migration, gene expression, and metabolism. Among these signaling molecules are the small GTPases RAS and RAP1, which induce MAPK pathways and cellular adhesion to activate downstream effector functions. Although many studies have helped to elucidate the signaling intermediates that mediate T cell activation, the molecules and pathways that keep naive T cells in check are less understood. Several recent studies provide evidence that RASA2 and RASA3, which are GAP1-family GTPase-activating proteins (GAPs) that inactivate RAS and RAP1, respectively, are crucial molecules that limit T cell activation and adhesion. In this review we describe recent data on the roles of RASA2 and RASA3 as gatekeepers of T cell activation and migration.
摘要：
在刺激之后,T细胞受体（TCR）及其共受体整合多个细胞内信号以启动T细胞增殖，迁移,基因表达，和新陈代谢。这些信号分子是小GTP酶RAS和RAP1,其诱导MAPK途径和细胞粘附以激活下游效应子功能。尽管许多研究有助于阐明介导T细胞活化的信号中间体，对保持幼稚T细胞的分子和途径了解较少。最近的一些研究提供了证据，RASA2和RASA3，它们是GAP1家族GTP酶激活蛋白（GAP），分别使RAS和RAP1失活，是限制T细胞活化和粘附的关键分子。在这篇综述中，我们描述了有关RASA2和RASA3作为T细胞激活和迁移的看门人的作用的最新数据。
