注意 GAP : RASA2 和 RASA3 GTP 酶激活蛋白是 T 细胞活化和粘附的守门人。
关键词: CRISPR/CAS9 GAP RAP1 RAS RASA2 RASA3 T cell proliferation T cell receptor signaling adhesion exhaustion integrins
Mesh : Humans GTPase-Activating Proteins / genetics metabolism Signal Transduction / physiology Cell Adhesion / physiology T-Lymphocytes / metabolism ras GTPase-Activating Proteins
来 源:
DOI:10.1016/j.it.2023.09.002
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