Abstract：
Proprioception, the sense of body position in space, has a critical role in the control of posture and movement. Aside from skin and joint receptors, the main sources of proprioceptive information in tetrapods are mechanoreceptive end organs in skeletal muscle: muscle spindles (MSs) and Golgi tendon organs (GTOs). The sensory neurons that innervate these receptors are divided into subtypes that detect discrete aspects of sensory information from muscles with different biomechanical functions. Despite the importance of proprioceptive neurons in motor control, the developmental mechanisms that control the acquisition of their distinct functional properties and positional identity are not yet clear. In this review, we discuss recent findings on the development of mouse proprioceptor subtypes and challenges in defining them at the molecular and functional level.
摘要：
本体感受,身体在空间中的位置感，在控制姿势和运动中起着至关重要的作用。除了皮肤和关节受体，四足动物本体感受信息的主要来源是骨骼肌的机械感受末端器官：肌肉纺锤体（MS）和高尔基肌腱器官（GTO）。支配这些受体的感觉神经元分为亚型，可检测来自具有不同生物力学功能的肌肉的感觉信息的离散方面。尽管本体感觉神经元在运动控制中很重要，控制其独特功能特性和位置同一性获得的发育机制尚不清楚。在这次审查中,我们讨论了小鼠本体感受器亚型发展的最新发现，以及在分子和功能水平上定义它们的挑战。
