Abstract：
Congenital syphilis, a significant cause of fetal mortality worldwide, is a congenital infectious disease instigated by the vertical transmission of Treponema pallidum during pregnancy. Clinical manifestations include preterm delivery, stillbirth, neonatal skin lesions, skeletal abnormalities, and central nervous system aberrations. The ongoing increase in the incidence of congenital syphilis, coupled with complexities in diagnosis, necessitates a detailed understanding of its pathogenesis for the development of improved diagnostic approaches, and to interrupt the route of vertical transmission. Drawing from the broader body of research associated with vertical transmission pathogens, we aim to clarify the potential mechanisms by which Treponema pallidum breaches the placental barrier to infect the fetus.
摘要：
先天性梅毒,全世界胎儿死亡的重要原因，是由妊娠期间梅毒螺旋体的垂直传播引起的先天性传染病。临床表现包括早产，死产,新生儿皮肤损伤,骨骼异常,和中枢神经系统畸变。先天性梅毒发病率的持续增加，再加上诊断的复杂性，需要详细了解其发病机理，以开发改进的诊断方法，并中断垂直传输的路线。从与垂直传播病原体相关的更广泛的研究中，我们旨在阐明梅毒螺旋体突破胎盘屏障感染胎儿的潜在机制。
