PDF(Pubmed)
Abstract：
UNASSIGNED: Habituation to pain is a fundamental learning process and important adaption. Yet, a comprehensive review of the current state of the field is lacking. Through a systematic search, 63 studies were included. Results address habituation to pain in healthy individuals based on self-report, electroencephalography, or functional magnetic resonance imaging. Our findings indicate a large variety in methods, experimental settings, and contexts, making habituation a ubiquitous phenomenon. Habituation to pain based on self-report studies shows a large influence of expectations, as well as the presence of individual differences. Furthermore, widespread neural effects, with sometimes opposing effects in self-report measures, are noted. Electroencephalography studies showed habituation of the N2-P2 amplitude, whereas functional magnetic resonance imaging studies showed decreasing activity during painful repeated stimulation in several identified brain areas (cingulate cortex and somatosensory cortices). Important considerations for the use of terminology, methodology, statistics, and individual differences are discussed. This review will aid our understanding of habituation to pain in healthy individuals and may lead the way to improving methods and designs for personalized treatment approaches in chronic pain patients.
摘要：
■习惯疼痛是一个基本的学习过程和重要的适应。然而，缺乏对该领域现状的全面审查。通过系统的搜索，共纳入63项研究。结果根据自我报告解决了健康个体对疼痛的习惯，脑电图,或者功能性磁共振成像.我们的发现表明方法多种多样，实验设置，和上下文，使习惯成为一种无处不在的现象。基于自我报告研究的疼痛习惯表明，期望有很大的影响，以及个体差异的存在。此外，广泛的神经效应，在自我报告措施中有时会产生相反的效果，被注意到。脑电图研究显示N2-P2振幅的习惯性，而功能磁共振成像研究显示，在几个确定的大脑区域（扣带皮质和体感皮质）的疼痛重复刺激期间，活动减少。使用术语的重要考虑因素，方法论，统计数据，并讨论了个体差异。这篇综述将帮助我们了解健康个体对疼痛的习惯，并可能为改善慢性疼痛患者个性化治疗方法的方法和设计提供帮助。
