Abstract：
The study of immune regulation mechanisms induced by parasites may help develop new treatment methods for inflammatory diseases including type 1 diabetes, which is related to type 1 immune responses. The negative correlation between schistosomiasis infection and type 1 diabetes has been confirmed, and the mechanism of Schistosoma-mediated prevention of type 1 diabetes may be related to the adaptive and innate immune systems. Schistosoma-related molecules affect immune cell composition and macrophage polarization and stimulate an increase in natural killer T cells. Furthermore, Schistosoma-related molecules can regulate the adaptive immune responses related to the prevention of type 1 diabetes and change the Th1/Th2 and Th17/Treg axis. Our previous review showed the role of regulatory T cells in the protective of type 1 diabetes mediated by Schistosoma. Here, we aim to review the other mechanisms of schistosomiasis infection and Schistosoma-related products in regulating the immune response associated with the treatment of type 1 diabetes.
摘要：
对寄生虫诱导的免疫调节机制的研究可能有助于开发包括1型糖尿病在内的炎症性疾病的新治疗方法。这与1型免疫反应有关。血吸虫病感染与1型糖尿病呈负相关,而血吸虫介导的预防1型糖尿病的机制可能与适应性和先天免疫系统有关。血吸虫相关分子影响免疫细胞组成和巨噬细胞极化并刺激自然杀伤T细胞的增加。此外，血吸虫相关分子可调节与预防1型糖尿病相关的适应性免疫应答,改变Th1/Th2和Th17/Treg轴。我们先前的综述显示调节性T细胞在保护由血吸虫介导的1型糖尿病中的作用。这里,我们旨在回顾血吸虫病感染和血吸虫相关产品在调节与1型糖尿病治疗相关的免疫反应方面的其他机制.
