Abstract：
Mexiletine, a class Ib antiarrhythmic drug, exhibits its major antiarrhythmic effect via inhibition of the fast and late Na+ currents in myocardial tissues that are dependent on the opening of Na+ channels for their excitation. Through a comprehensive examination of mexiletine\'s therapeutic benefits and potential risks, we aim to provide valuable insights that reinforce its role as a vital therapeutic option for patients with ventricular arrhythmias, long QT syndrome, and other heart rhythm disorders. This review will highlight the current understandings of the antiarrhythmic effects and rationales for recent off-label use and address the mortality and proarrhythmic effects of mexiletine utilizing published basic and clinical studies over the past five decades.
摘要：
美西律,Ib类抗心律失常药，通过抑制心肌组织中的快速和晚期Na电流表现出其主要的抗心律失常作用，该作用取决于Na通道的开放以激发它们。通过全面检查美西律的治疗益处和潜在风险，我们的目标是提供有价值的见解，加强其作为室性心律失常患者的重要治疗选择的作用，长QT综合征,和其他心律紊乱.这篇综述将重点介绍当前对抗心律失常作用的理解和最近标签外使用的基本原理，并利用过去五十年中已发表的基础和临床研究来解决美西律的死亡率和致心律失常作用。
