Abstract：
BACKGROUND: Acinetobacter baumannii produce biofilm and efflux pumps. This systematic review study aimed to provide new strategies to inhibit the efflux pumps and biofilm in A. baumannii using nanoparticles.
METHODS: In this research, analyses from 2000 to February 24, 2022, were performed by the Statement of Preferred Reporting Items for Systematic Reviews (PRISMA). Keywords include Acinetobacter baumannii (A. baumannii) AND (biofilm) AND (anti-biofilm activity) AND (nanoparticles) AND (solid lipid NPS) AND (lipid nanocarriers), and in other searches include Acinetobacter baumannii (A. baumanni) AND (efflux pumps) AND (nanoparticles) AND (solid lipid NPS) AND (lipid nanocarriers). Searches were conducted in English databases, including Science Direct, PubMed, Scopus, Ovid, and Cochrane.
RESULTS: At first, 136 studies were extracted, but after removing duplicates, 116 cases remained for further analysis. After evaluating the title and abstract of each study, 95 unrelated studies were excluded. The remaining 25 studies were reviewed based on full texts. Considering the inclusion/exclusion criteria, 19 studies were selected. In this study, metal nanoparticles were the most used nanoparticles for anti-biofilm and efflux pump purposes, and among these nanoparticles, silver nanoparticles (AgNPs) contributed the most.
CONCLUSIONS: The present study shows that nanoparticles have potential and significant effects in inhibiting biofilm and efflux pumps in A. baumannii isolates, which researchers can consider in light of the increasing prevalence of antibiotic resistance.
METHODS: In this research, analyses from 2000 to February 24, 2022, were performed by the Statement of Preferred Reporting Items for Systematic Reviews (PRISMA). Keywords include Acinetobacter baumannii (A. baumannii) AND (biofilm) AND (anti-biofilm activity) AND (nanoparticles) AND (solid lipid NPS) AND (lipid nanocarriers), and in other searches include Acinetobacter baumannii (A. baumanni) AND (efflux pumps) AND (nanoparticles) AND (solid lipid NPS) AND (lipid nanocarriers). Searches were conducted in English databases, including Science Direct, PubMed, Scopus, Ovid, and Cochrane.
RESULTS: At first, 136 studies were extracted, but after removing duplicates, 116 cases remained for further analysis. After evaluating the title and abstract of each study, 95 unrelated studies were excluded. The remaining 25 studies were reviewed based on full texts. Considering the inclusion/exclusion criteria, 19 studies were selected. In this study, metal nanoparticles were the most used nanoparticles for anti-biofilm and efflux pump purposes, and among these nanoparticles, silver nanoparticles (AgNPs) contributed the most.
CONCLUSIONS: The present study shows that nanoparticles have potential and significant effects in inhibiting biofilm and efflux pumps in A. baumannii isolates, which researchers can consider in light of the increasing prevalence of antibiotic resistance.
摘要：
背景：鲍曼不动杆菌产生生物膜和外排泵。本系统综述研究旨在提供使用纳米颗粒抑制鲍曼不动杆菌外排泵和生物膜的新策略。
方法：在这项研究中，2000年至2022年2月24日的分析由系统审查首选报告项目声明(PRISMA)进行。关键词包括鲍曼不动杆菌(A.鲍曼不动）和（生物膜）和（抗生物膜活性）和（纳米颗粒）和（固体脂质NPS）和（脂质纳米载体），在其他搜索中包括鲍曼不动杆菌（A.鲍曼尼）和（外排泵）和（纳米颗粒）和（固体脂质NPS）和（脂质纳米载体）。在英文数据库中进行搜索，包括科学直接，PubMed,Scopus,奥维德,还有Cochrane.
结果：首先，提取了136项研究，但是在删除重复项之后，116例仍有待进一步分析。在评估了每项研究的标题和摘要之后，95项无关的研究被排除在外。根据全文对其余25项研究进行了回顾。考虑到纳入/排除标准，选择了19项研究。在这项研究中,金属纳米粒子是用于抗生物膜和外排泵目的的最常用的纳米粒子，在这些纳米粒子中，银纳米粒子(AgNPs)的贡献最大。
结论：本研究表明，纳米颗粒在抑制鲍曼不动杆菌分离物中的生物膜和外排泵方面具有潜在和显着的作用，鉴于抗生素耐药性的日益普遍，研究人员可以考虑这一点。
方法：在这项研究中，2000年至2022年2月24日的分析由系统审查首选报告项目声明(PRISMA)进行。关键词包括鲍曼不动杆菌(A.鲍曼不动）和（生物膜）和（抗生物膜活性）和（纳米颗粒）和（固体脂质NPS）和（脂质纳米载体），在其他搜索中包括鲍曼不动杆菌（A.鲍曼尼）和（外排泵）和（纳米颗粒）和（固体脂质NPS）和（脂质纳米载体）。在英文数据库中进行搜索，包括科学直接，PubMed,Scopus,奥维德,还有Cochrane.
结果：首先，提取了136项研究，但是在删除重复项之后，116例仍有待进一步分析。在评估了每项研究的标题和摘要之后，95项无关的研究被排除在外。根据全文对其余25项研究进行了回顾。考虑到纳入/排除标准，选择了19项研究。在这项研究中,金属纳米粒子是用于抗生物膜和外排泵目的的最常用的纳米粒子，在这些纳米粒子中，银纳米粒子(AgNPs)的贡献最大。
结论：本研究表明，纳米颗粒在抑制鲍曼不动杆菌分离物中的生物膜和外排泵方面具有潜在和显着的作用，鉴于抗生素耐药性的日益普遍，研究人员可以考虑这一点。
