PDF(Pubmed)
Abstract：
(1) Background: Long COVID syndrome (LCS) is a heterogeneous long-standing condition following COVID-19 infection. Treatment options are limited to symptomatic measures, and no specific medication has been established. Hyperbaric oxygenation (HBO) has been found to have a positive impact on the treatment of COVID-19 infection. This study evaluates both the feasibility and outcome of supportive HBO in patients with LCS. (2) Methods: Within 17 months, 70 patients with proven LCS were prospectively included. Each patient underwent a cycle of 10 subsequent HBO treatment sessions administered for 75 min at 2.2 atmospheres. Evaluation of the patients was performed before the first and after the last HBO session and 3 months afterwards. Statistical evaluation was based on an intention-to-treat analysis using Fisher\'s exact test and Student\'s t-test for paired samples. (3) Results: In total, 59 patients (33 females, 26 males; mean age: 43.9 years; range: 23-74 years; median: 45.0) were evaluable. After HBO, a statistically significant improvement of physical functioning (p < 0.001), physical role (p = 0.01), energy (p < 0.001), emotional well-being (p < 0.001), social functioning (p < 0.001), pain (p = 0.01) and reduced limitation of activities (p < 0.001) was confirmed. (4) Conclusions: Physical functioning and both the physical and emotional role improved significantly and sustainably, suggesting HBO as a promising supportive therapeutic tool for the treatment of LCS.
摘要：
（1）背景：长型COVID综合征（LCS）是COVID-19感染后的长期异质性疾病。治疗方案仅限于对症措施，还没有确定具体的药物。已发现高压氧（HBO）对COVID-19感染的治疗具有积极影响。这项研究评估了支持性HBO在LCS患者中的可行性和结果。（2）方法：17个月内，前瞻性纳入了70例确诊的LCS患者。每位患者在2.2个大气压下进行持续75分钟的10次后续HBO治疗。在第一次和最后一次HBO治疗之前以及3个月后对患者进行评估。统计评估基于对配对样品使用Fisher精确检验和Studentt检验的意向治疗分析。（3）结果：总的来说，59名患者（33名女性，26名男性；平均年龄：43.9岁；范围：23-74岁；中位数：45.0）可评估。HBO之后,身体功能的统计学显着改善（p<0.001），身体作用(p=0.01)，能量(p<0.001)，情绪幸福感(p<0.001)，社会功能（p<0.001），疼痛（p=0.01）和活动限制降低（p<0.001）得到证实。（4）结论：身体功能和身体和情感的作用显著和可持续的改善，表明HBO是治疗LCS的一种有前途的支持性治疗工具。
