PDF(Pubmed)
Abstract：
Staphylococci are major causes of infections in mammals. Mammals are colonized by diverse staphylococcal species, often with moderate to strong host specificity, and colonization is a common source of infection. Staphylococcal infections of animals not only are of major importance for animal well-being but have considerable economic consequences, such as in the case of staphylococcal mastitis, which costs billions of dollars annually. Furthermore, pet animals can be temporary carriers of strains infectious to humans. Moreover, antimicrobial resistance is a great concern in livestock infections, as there is considerable antibiotic overuse, and resistant strains can be transferred to humans. With the number of working antibiotics continuously becoming smaller due to the concomitant spread of resistant strains, alternative approaches, such as anti-virulence, are increasingly being investigated to treat staphylococcal infections. For this, understanding the virulence mechanisms of animal staphylococcal pathogens is crucial. While many virulence factors have similar functions in humans as animals, there are increasingly frequent reports of host-specific virulence factors and mechanisms. Furthermore, we are only beginning to understand virulence mechanisms in animal-specific staphylococcal pathogens. This review gives an overview of animal infections caused by staphylococci and our knowledge about the virulence mechanisms involved.
摘要：
葡萄球菌是哺乳动物感染的主要原因。哺乳动物被不同的葡萄球菌物种定植，通常具有中等到强的宿主特异性，定植是常见的感染源。动物的葡萄球菌感染不仅对动物的健康至关重要，而且具有相当大的经济后果。例如在葡萄球菌性乳腺炎的情况下，每年花费数十亿美元。此外，宠物动物可以是对人类有传染性的菌株的临时携带者。此外，抗菌素耐药性是家畜感染中一个非常令人担忧的问题，因为有相当多的抗生素过度使用，抗性菌株可以转移给人类。随着耐药菌株的传播，工作抗生素的数量不断减少，替代方法，例如抗毒力，越来越多的研究用于治疗葡萄球菌感染。为此，了解动物葡萄球菌病原体的毒力机制至关重要。虽然许多毒力因子在人类和动物中具有相似的功能，宿主特异性毒力因子和机制的报道越来越频繁。此外，我们才刚刚开始了解动物特异性葡萄球菌病原体的毒力机制.这篇综述概述了由葡萄球菌引起的动物感染以及我们对所涉及的毒力机制的了解。
