Abstract：
OBJECTIVE: The prevalence of obesity and overweight in children has been increasing rapidly worldwide and threatens society with various chronic diseases that these children are born with. High-protein ketogenic diets and intermittent nutrition are thought to be protective against obesity and metabolic syndrome MetS. However, the exact effects and results, insulin resistance, and the role of leptin in the functioning mechanism of these diets have not been fully elucidated. The aim of this study was to investigate the roles of insulin resistance and leptin hormone on the effects of body composition with a high-protein ketogenic diet and intermittent nutrition combination.
METHODS: Thirty-two young non-obese rats were randomly divided into four equal groups. Both the standard diet and the high-protein ketogenic diet were given ad libitum and intermittently to the rats for 6 wk. The body weight and fat mass of the rats were measured at the end of the experiment. The fasting glucose, leptin, insulin, high- and low-density lipoprotein, and triacylglycerols were measured with the blood samples.
RESULTS: The lowest body weight was observed in the intermittent and high-protein ketogenic diet group, followed by the free high-protein ketogenic diet and standard intermittent diet group, respectively. Also, the lowest body fat mass was observed in the intermittent and high-protein ketogenic diet group, followed by the standard intermittent diet group. Although there was no change in leptin, insulin, high- and low-density lipoprotein, and triacylglycerol levels in any group, the lowest blood glucose rate was observed in the intermittent and high-protein ketogenic diet group.
CONCLUSIONS: The results of the present study revealed that an intermittent high-protein ketogenic diet is more effective than others in weight loss without disrupting biochemical health parameters, and the applied diets do not prevent growth and development.
METHODS: Thirty-two young non-obese rats were randomly divided into four equal groups. Both the standard diet and the high-protein ketogenic diet were given ad libitum and intermittently to the rats for 6 wk. The body weight and fat mass of the rats were measured at the end of the experiment. The fasting glucose, leptin, insulin, high- and low-density lipoprotein, and triacylglycerols were measured with the blood samples.
RESULTS: The lowest body weight was observed in the intermittent and high-protein ketogenic diet group, followed by the free high-protein ketogenic diet and standard intermittent diet group, respectively. Also, the lowest body fat mass was observed in the intermittent and high-protein ketogenic diet group, followed by the standard intermittent diet group. Although there was no change in leptin, insulin, high- and low-density lipoprotein, and triacylglycerol levels in any group, the lowest blood glucose rate was observed in the intermittent and high-protein ketogenic diet group.
CONCLUSIONS: The results of the present study revealed that an intermittent high-protein ketogenic diet is more effective than others in weight loss without disrupting biochemical health parameters, and the applied diets do not prevent growth and development.
摘要：
目的：儿童肥胖和超重的患病率在全球范围内迅速增加，并威胁着这些儿童与生俱来的各种慢性疾病。高蛋白生酮饮食和间歇性营养被认为可以预防肥胖和代谢综合征。然而,确切的效果和结果，胰岛素抵抗，瘦素在这些饮食的作用机制中的作用尚未完全阐明。这项研究的目的是研究胰岛素抵抗和瘦素激素对高蛋白生酮饮食和间歇性营养组合对身体成分影响的作用。
方法：将32只幼年非肥胖大鼠随机分为4组。标准饮食和高蛋白生酮饮食均随意给予大鼠，并间歇性给予大鼠6周。在实验结束时测量大鼠的体重和脂肪量。空腹血糖，瘦素,胰岛素，高密度和低密度脂蛋白，和三酰甘油用血样测定。
结果：在间歇性和高蛋白生酮饮食组中观察到最低体重，其次是免费高蛋白生酮饮食和标准间歇饮食组，分别。此外，在间歇性和高蛋白生酮饮食组中观察到最低的体脂质量，其次是标准间歇饮食组。虽然瘦素没有变化,胰岛素，高密度和低密度脂蛋白，和三酰甘油在任何组中的水平，间歇性和高蛋白生酮饮食组的血糖率最低.
结论：本研究的结果表明，间歇性高蛋白生酮饮食在减肥方面比其他饮食更有效，而不会破坏生化健康参数，和应用的饮食不阻止生长和发育。
方法：将32只幼年非肥胖大鼠随机分为4组。标准饮食和高蛋白生酮饮食均随意给予大鼠，并间歇性给予大鼠6周。在实验结束时测量大鼠的体重和脂肪量。空腹血糖，瘦素,胰岛素，高密度和低密度脂蛋白，和三酰甘油用血样测定。
结果：在间歇性和高蛋白生酮饮食组中观察到最低体重，其次是免费高蛋白生酮饮食和标准间歇饮食组，分别。此外，在间歇性和高蛋白生酮饮食组中观察到最低的体脂质量，其次是标准间歇饮食组。虽然瘦素没有变化,胰岛素，高密度和低密度脂蛋白，和三酰甘油在任何组中的水平，间歇性和高蛋白生酮饮食组的血糖率最低.
结论：本研究的结果表明，间歇性高蛋白生酮饮食在减肥方面比其他饮食更有效，而不会破坏生化健康参数，和应用的饮食不阻止生长和发育。
