Abstract：
OBJECTIVE: To investigate the effect of obesity on fetal cortical development.
METHODS: This prospective cross-sectional study was conducted with 91 pregnant women. Fetal neurosonography scans were performed in the third trimester, and according to body mass index (BMI) values, the patients were evaluated in two groups: obese (BMI ≥ 30 kg/m2) and normal weight (BMI < 30 kg/m2). During neurosonography, fetal insular depth and Sylvian fissures, parieo-occipital and cingulate fissure depth, frontal lobe length, and the sizes of the corpus callosum and cavum septum pellucidum were measured using a transvaginal approach. Fetal cortical development and Sylvian fissure operculization were graded.
RESULTS: The number of patients with grade 2 fetal cortical development was significantly higher among the pregnant women in the obese group compared to the normal weight group (n = 17, 41.5% and n = 8, 16.0%, respectively; p = 0.007). In the obese group, the number of pregnant women with grade 4 or below fetal Sylvian fissure operculization was significantly higher (n = 13, 31.7%), and the number of those with grade 9 or above operculization was significantly lower (n = 1, 2.5%) (p = 0.003). The fetal insular depth, frontal lobe anterior-posterior diameter, cingulate fissure depth, and corpus callosum thickness were lower in the obese group, albeit with no significant difference. Parieto-occipital depth significantly decreased in the obese group [6.8 (6) mm)] compared to the control group [10.5 (7.2) mm)] (p = 0.008). The fetal Sylvian fissure ratio and the cavum septum pellucidum ratio were found to be similar between the groups.
CONCLUSIONS: The data obtained from this study showed that obesity caused fetal cortical changes in pregnant women.
METHODS: This prospective cross-sectional study was conducted with 91 pregnant women. Fetal neurosonography scans were performed in the third trimester, and according to body mass index (BMI) values, the patients were evaluated in two groups: obese (BMI ≥ 30 kg/m2) and normal weight (BMI < 30 kg/m2). During neurosonography, fetal insular depth and Sylvian fissures, parieo-occipital and cingulate fissure depth, frontal lobe length, and the sizes of the corpus callosum and cavum septum pellucidum were measured using a transvaginal approach. Fetal cortical development and Sylvian fissure operculization were graded.
RESULTS: The number of patients with grade 2 fetal cortical development was significantly higher among the pregnant women in the obese group compared to the normal weight group (n = 17, 41.5% and n = 8, 16.0%, respectively; p = 0.007). In the obese group, the number of pregnant women with grade 4 or below fetal Sylvian fissure operculization was significantly higher (n = 13, 31.7%), and the number of those with grade 9 or above operculization was significantly lower (n = 1, 2.5%) (p = 0.003). The fetal insular depth, frontal lobe anterior-posterior diameter, cingulate fissure depth, and corpus callosum thickness were lower in the obese group, albeit with no significant difference. Parieto-occipital depth significantly decreased in the obese group [6.8 (6) mm)] compared to the control group [10.5 (7.2) mm)] (p = 0.008). The fetal Sylvian fissure ratio and the cavum septum pellucidum ratio were found to be similar between the groups.
CONCLUSIONS: The data obtained from this study showed that obesity caused fetal cortical changes in pregnant women.
摘要：
目的：探讨肥胖对胎儿皮质发育的影响。
方法：这项前瞻性横断面研究对91名孕妇进行。在妊娠晚期进行胎儿神经超声扫描，根据体重指数(BMI)值，将患者分为两组:肥胖(BMI≥30kg/m2)和正常体重(BMI<30kg/m2).在神经超声检查期间，胎儿岛礁深度和Sylvian裂隙，顶枕骨和扣带裂隙深度，额叶长度,使用经阴道方法测量call体和透明隔腔的大小。胎儿皮质发育和Sylvian裂手术分级。
结果:与体重正常组相比,肥胖组孕妇中胎儿皮质发育2级的患者数量明显高于正常组(n=17,41.5%,n=8,16.0%,分别为；p=0.007)。在肥胖组中，4级及以下胎儿Sylvian裂手术的孕妇人数明显更高（n=13，31.7％），9级或以上操作的数量显着减少（n=1，2.5％）（p=0.003）。胎岛深度，额叶前后直径，扣带裂隙深度,肥胖组call体厚度较低，尽管没有显著差异。与对照组[10.5（7.2）mm]相比，肥胖组[6.8（6）mm]的枕骨深度显着降低（p=0.008）。发现两组之间的胎儿Sylvian裂比率和透明腔间隔比率相似。
结论：这项研究获得的数据表明，肥胖导致孕妇的胎儿皮质改变。
方法：这项前瞻性横断面研究对91名孕妇进行。在妊娠晚期进行胎儿神经超声扫描，根据体重指数(BMI)值，将患者分为两组:肥胖(BMI≥30kg/m2)和正常体重(BMI<30kg/m2).在神经超声检查期间，胎儿岛礁深度和Sylvian裂隙，顶枕骨和扣带裂隙深度，额叶长度,使用经阴道方法测量call体和透明隔腔的大小。胎儿皮质发育和Sylvian裂手术分级。
结果:与体重正常组相比,肥胖组孕妇中胎儿皮质发育2级的患者数量明显高于正常组(n=17,41.5%,n=8,16.0%,分别为；p=0.007)。在肥胖组中，4级及以下胎儿Sylvian裂手术的孕妇人数明显更高（n=13，31.7％），9级或以上操作的数量显着减少（n=1，2.5％）（p=0.003）。胎岛深度，额叶前后直径，扣带裂隙深度,肥胖组call体厚度较低，尽管没有显著差异。与对照组[10.5（7.2）mm]相比，肥胖组[6.8（6）mm]的枕骨深度显着降低（p=0.008）。发现两组之间的胎儿Sylvian裂比率和透明腔间隔比率相似。
结论：这项研究获得的数据表明，肥胖导致孕妇的胎儿皮质改变。
