PDF(Pubmed)
Abstract：
The genetic basis of dentoalveolar characteristics has been investigated by several studies, however, the findings are equivocal. The objective of this systematic review and meta-analysis was to evaluate the heritability of dental arches and occlusal parameters in different stages of human dentition.
Electronic databases PubMed, Embase, Scopus, Web of Science, and Dentistry and Oral Science Source were searched up to August 2023 without the restriction of language or publication date.
Empirical studies investigating the heritability of dentoalveolar parameters among twins and siblings were included in the review.
Study selection, data extraction, and risk of bias assessment were performed independently and in duplicate by two authors and a third author resolved conflicts if needed. Joanna Briggs Institute\'s critical appraisal tool was used to evaluate the risk of bias among studies and the certainty of evidence was assessed using the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) criteria.
Twenty-eight studies were included in the systematic review, of which 15 studies reporting heritability coefficients in the permanent dentition stages were deemed suitable for the meta-analysis. Random-effects meta-analyses showed high heritability estimates for maxillary intermolar width (0.52), maxillary intercanine width (0.54), mandibular intermolar width (0.55), mandibular intercanine width (0.55), maxillary arch length (0.76), mandibular arch length (0.57), and palatal depth (0.56). The heritability estimates for the occlusal parameters varied considerably, with relatively moderate values for crossbite (0.46) and overbite (0.44) and low values for buccal segment relationship (0.32), overjet (0.22), and rotation and displacement of teeth (0.16). However, the certainty of evidence for most of the outcomes was low according to the GRADE criteria.
Based on the available evidence, it can be concluded that the dental arch dimensions have a high heritability while the occlusal parameters demonstrate a moderate to low heritability.
PROSPERO (CRD42022358442).
Electronic databases PubMed, Embase, Scopus, Web of Science, and Dentistry and Oral Science Source were searched up to August 2023 without the restriction of language or publication date.
Empirical studies investigating the heritability of dentoalveolar parameters among twins and siblings were included in the review.
Study selection, data extraction, and risk of bias assessment were performed independently and in duplicate by two authors and a third author resolved conflicts if needed. Joanna Briggs Institute\'s critical appraisal tool was used to evaluate the risk of bias among studies and the certainty of evidence was assessed using the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) criteria.
Twenty-eight studies were included in the systematic review, of which 15 studies reporting heritability coefficients in the permanent dentition stages were deemed suitable for the meta-analysis. Random-effects meta-analyses showed high heritability estimates for maxillary intermolar width (0.52), maxillary intercanine width (0.54), mandibular intermolar width (0.55), mandibular intercanine width (0.55), maxillary arch length (0.76), mandibular arch length (0.57), and palatal depth (0.56). The heritability estimates for the occlusal parameters varied considerably, with relatively moderate values for crossbite (0.46) and overbite (0.44) and low values for buccal segment relationship (0.32), overjet (0.22), and rotation and displacement of teeth (0.16). However, the certainty of evidence for most of the outcomes was low according to the GRADE criteria.
Based on the available evidence, it can be concluded that the dental arch dimensions have a high heritability while the occlusal parameters demonstrate a moderate to low heritability.
PROSPERO (CRD42022358442).
摘要：
目的：牙槽细胞特征的遗传基础已通过多项研究进行了研究，然而,调查结果是模棱两可的。这项系统评价和荟萃分析的目的是评估人类牙列不同阶段牙弓和咬合参数的遗传性。
方法：电子数据库PubMed，Embase,Scopus,WebofScience,直到2023年8月，在没有语言或出版日期限制的情况下，搜索了牙科和口腔科学来源。
方法：本综述包括调查双胞胎和兄弟姐妹牙槽参数遗传度的实证研究。
方法：研究选择，数据提取,和偏倚风险评估由两名作者独立且一式两份进行,如果需要,第三作者解决了冲突.JoannaBriggs研究所的关键评估工具用于评估研究中的偏倚风险，并使用建议分级评估证据的确定性，评估,发展,和评估（等级）标准。
结果：28项研究纳入系统评价，其中15项报告恒牙阶段遗传力系数的研究被认为适用于荟萃分析。随机效应荟萃分析显示上颌磨牙间宽度的高遗传度估计值（0.52），上颌齿间宽度（0.54），下颌磨牙间宽度（0.55），下颌间宽度（0.55），上颌弓长度（0.76），下颌弓长（0.57），和腭深（0.56）。咬合参数的遗传力估计差异很大，交叉咬合（0.46）和过咬合（0.44）的值相对适中，颊段关系的值较低（0.32），喷射机(0.22)，和旋转和位移的牙齿（0.16）。然而,根据GRADE标准,大多数结局的证据确定性较低.
结论：根据现有证据，可以得出结论，牙弓尺寸具有较高的遗传力，而咬合参数显示中等至较低的遗传力。
背景：PROSPERO（CRD42022358442）。
方法：电子数据库PubMed，Embase,Scopus,WebofScience,直到2023年8月，在没有语言或出版日期限制的情况下，搜索了牙科和口腔科学来源。
方法：本综述包括调查双胞胎和兄弟姐妹牙槽参数遗传度的实证研究。
方法：研究选择，数据提取,和偏倚风险评估由两名作者独立且一式两份进行,如果需要,第三作者解决了冲突.JoannaBriggs研究所的关键评估工具用于评估研究中的偏倚风险，并使用建议分级评估证据的确定性，评估,发展,和评估（等级）标准。
结果：28项研究纳入系统评价，其中15项报告恒牙阶段遗传力系数的研究被认为适用于荟萃分析。随机效应荟萃分析显示上颌磨牙间宽度的高遗传度估计值（0.52），上颌齿间宽度（0.54），下颌磨牙间宽度（0.55），下颌间宽度（0.55），上颌弓长度（0.76），下颌弓长（0.57），和腭深（0.56）。咬合参数的遗传力估计差异很大，交叉咬合（0.46）和过咬合（0.44）的值相对适中，颊段关系的值较低（0.32），喷射机(0.22)，和旋转和位移的牙齿（0.16）。然而,根据GRADE标准,大多数结局的证据确定性较低.
结论：根据现有证据，可以得出结论，牙弓尺寸具有较高的遗传力，而咬合参数显示中等至较低的遗传力。
背景：PROSPERO（CRD42022358442）。
