PDF(Pubmed)
Abstract：
Castleman disease (CD) is a rare lymphoproliferative disorder that is associated with an increased risk for lymphoma. The association between CD and classical Hodgkin lymphoma (HL) is rare. The patient described here is a 44-year-old, HIV-seronegative male who presented with significant weight loss, fever, night sweats, and right axillary swelling. Imaging showed bulky infraclavicular, subpectoral, and axillary lymph nodes. A biopsy revealed classical HL on the background of a human herpesvirus-8 (HHV-8)-negative plasma cell variant of CD. The patient had a complete remission after six cycles of doxorubicin, bleomycin, vincristine, and dacarbazine (ABVD) that were followed by consolidative radiotherapy and continued to be disease-free for more than two years.
摘要：
Castleman病（CD）是一种罕见的淋巴增生性疾病，与淋巴瘤的风险增加有关。CD与经典霍奇金淋巴瘤（HL）之间的关联很少。这里描述的病人是一个44岁的人,HIV血清阴性的男性表现出明显的体重减轻，发烧,盗汗,和右腋窝肿胀。影像学显示锁骨下体积庞大，胸下,和腋窝淋巴结.活检显示，在人类疱疹病毒8（HHV-8）阴性CD浆细胞变体的背景下，经典的HL。患者在六个周期的阿霉素治疗后完全缓解，博来霉素,长春新碱,和达卡巴嗪（ABVD），随后进行巩固性放疗，并继续无病超过两年。
