PDF(Pubmed)
Abstract：
The common human coronaviruses (HCoVs) HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1 which are members of the coronavirus family are long co-existed with humans and widely distributed globally. Common HCoVs usually cause mild, self-limited upper respiratory tract infections (URTI), and also associated with lower respiratory tract infections (LRTI), especially in children. However, there are little multicentre studies have been conducted in children of several different areas in China, and the epidemic potential of common HCoVs remains unclear. Understanding of the common HCoVs is valuable for clinical and public health. Herein, we retrospectively analysed the medical records of children with acute lower respiratory tract infection admitted to 9 hospitals from different regions in China from 2014 to 2019. Of the 124 patients who tested positive for coronaviruses, OC43 was the predominant type, accounting for 36.3% (45/124) of the detections. Children aged ≤ 6 months and 12-23 months had the highest detection rate of common HCoVs, and the detection rate gradually declined after 2 years old. These four HCoVs could be detected all year round. Among the areas of our study, the overall positive rate was higher in southern China, especially in Guangzhou (29/124, 23.4%). Moreover, common HCoV-positive patients were codetected with 9 other common respiratory pathogens. 229E (11/13, 84.6%) was the most frequently associated with codetection, with EV/RhV was the most frequently codetected virus. Cough (113/124, 91.1%) and fever (73/124, 58.9%) were the most common symptoms of common HCoVs infection.
摘要：
常见的人类冠状病毒（HCoV）HCoV-229E，作为冠状病毒家族成员的HCoV-OC43，HCoV-NL63和HCoV-HKU1长期与人类共存，并在全球广泛分布。常见的HCoV通常引起轻度，自限性上呼吸道感染（URTI），还与下呼吸道感染（LRTI）有关，尤其是儿童。然而,很少有多中心研究在中国几个不同地区的儿童中进行，常见HCoV的流行潜力仍不清楚。了解常见的HCoV对临床和公共卫生很有价值。在这里，我们回顾性分析了2014年至2019年中国不同地区9家医院收治的急性下呼吸道感染患儿的病历资料.在124名冠状病毒检测呈阳性的患者中，OC43是主要类型，占检出率的36.3%(45/124)。≤6个月和12-23个月的儿童对常见HCoV的检出率最高，2岁后检出率逐渐下降。这四个HCoV可以全年检测到。在我们研究的领域中，中国南方的总体阳性率较高，特别是广州（29/124，23.4%）。此外，常见HCoV阳性患者与其他9种常见呼吸道病原体同时检测.229E(11/13，84.6%)与共检测最常见，EV/RhV是最常见的共同检测病毒。咳嗽(113/124,91.1%)和发热(73/124,58.9%)是常见HCoV感染的最常见症状。
