Abstract：
OBJECTIVE: To investigate the differences of the nasal soft and hard tissue asymmetry in postoperative patients with unilateral cleft lip and palate (UCLP) between adolescence and adulthood, and to explore the correlation of nasal soft and hard tissue asymmetry.
METHODS: CT data from 47 repaired UCLP patients were included and divided into two groups:1. adolescent group: 23 patients (15 males, 8 females; age: 10-12 years old). 2. adult group: 24 patients (16 males, 8 females; age:18-32 years old). The three-dimensional asymmetry in nasal soft and hard tissues was analyzed. Additionally, the correlation between nasal soft and hard tissue asymmetry was also analyzed.
RESULTS: Both the adolescent group and adult group showed asymmetries in nasal soft and hard tissues. Compared to the adolescent group, the adult group had a significantly increased horizontal asymmetry of nasal soft tissues Sbal (P < 0.05). Furthermore, the sagittal asymmetry of soft tissue Glat (P < 0.05), Sbal (P < 0.001), Sni (P < 0.001) and hard tissue LPA (P < 0.05) also increased significantly. In the adult group, there were more landmarks with a correlation between the asymmetry of nasal hard tissue and soft tissue compared to the adolescent group. There were moderate to strong correlations between nasal hard and soft tissue symmetries in the horizontal and sagittal directions (0.444 < r < 764), but no correlation in the vertical direction in the adult group (P > 0.05).
CONCLUSIONS: The asymmetry of nasal soft and hard tissues in patients with repaired UCLP becomes more apparent in the horizontal and sagittal dimensions from adolescence to adulthood. The correlation between the asymmetry of nasal hard tissue and soft tissue becomes stronger in the horizontal and sagittal dimensions. These factors should be taken into account when performing treatment for repaired UCLP patients in adolescence and adulthood.
METHODS: CT data from 47 repaired UCLP patients were included and divided into two groups:1. adolescent group: 23 patients (15 males, 8 females; age: 10-12 years old). 2. adult group: 24 patients (16 males, 8 females; age:18-32 years old). The three-dimensional asymmetry in nasal soft and hard tissues was analyzed. Additionally, the correlation between nasal soft and hard tissue asymmetry was also analyzed.
RESULTS: Both the adolescent group and adult group showed asymmetries in nasal soft and hard tissues. Compared to the adolescent group, the adult group had a significantly increased horizontal asymmetry of nasal soft tissues Sbal (P < 0.05). Furthermore, the sagittal asymmetry of soft tissue Glat (P < 0.05), Sbal (P < 0.001), Sni (P < 0.001) and hard tissue LPA (P < 0.05) also increased significantly. In the adult group, there were more landmarks with a correlation between the asymmetry of nasal hard tissue and soft tissue compared to the adolescent group. There were moderate to strong correlations between nasal hard and soft tissue symmetries in the horizontal and sagittal directions (0.444 < r < 764), but no correlation in the vertical direction in the adult group (P > 0.05).
CONCLUSIONS: The asymmetry of nasal soft and hard tissues in patients with repaired UCLP becomes more apparent in the horizontal and sagittal dimensions from adolescence to adulthood. The correlation between the asymmetry of nasal hard tissue and soft tissue becomes stronger in the horizontal and sagittal dimensions. These factors should be taken into account when performing treatment for repaired UCLP patients in adolescence and adulthood.
摘要：
目的：探讨单侧唇腭裂(UCLP)患者术后鼻部软组织和硬组织不对称性在青春期和成年期的差异。并探讨鼻腔软硬组织不对称性的相关性。
方法：纳入47例UCLP修复患者的CT数据，分为两组：1.青少年组：23例（15例男性，8名女性；年龄：10-12岁）。2.成人组：24名患者（16名男性，8名女性；年龄：18-32岁）。分析了鼻腔软组织和硬组织的三维不对称性。此外,还分析了鼻软组织和硬组织不对称之间的相关性。
结果：青少年组和成人组均显示鼻腔软组织和硬组织不对称。与青少年组相比，成年组鼻部软组织水平不对称性显著增加(P<0.05)。此外，软组织Glat矢状不对称(P<0.05),Sbal（P<0.001），Sni(P<0.001)和硬组织LPA(P<0.05)也显著增高。在成人组中,与青少年组相比,鼻部硬组织和软组织的不对称性之间存在更多相关标志.鼻腔硬组织和软组织对称性在水平和矢状方向上有中等到强的相关性（0.4440.05)。
结论：经修复的UCLP患者鼻腔软组织和硬组织的不对称性在从青春期到成年期的水平和矢状尺寸上变得更加明显。鼻硬组织和软组织的不对称性在水平和矢状尺寸上的相关性变得更强。在对青春期和成年期的UCLP修复患者进行治疗时，应考虑这些因素。
方法：纳入47例UCLP修复患者的CT数据，分为两组：1.青少年组：23例（15例男性，8名女性；年龄：10-12岁）。2.成人组：24名患者（16名男性，8名女性；年龄：18-32岁）。分析了鼻腔软组织和硬组织的三维不对称性。此外,还分析了鼻软组织和硬组织不对称之间的相关性。
结果：青少年组和成人组均显示鼻腔软组织和硬组织不对称。与青少年组相比，成年组鼻部软组织水平不对称性显著增加(P<0.05)。此外，软组织Glat矢状不对称(P<0.05),Sbal（P<0.001），Sni(P<0.001)和硬组织LPA(P<0.05)也显著增高。在成人组中,与青少年组相比,鼻部硬组织和软组织的不对称性之间存在更多相关标志.鼻腔硬组织和软组织对称性在水平和矢状方向上有中等到强的相关性（0.444
结论：经修复的UCLP患者鼻腔软组织和硬组织的不对称性在从青春期到成年期的水平和矢状尺寸上变得更加明显。鼻硬组织和软组织的不对称性在水平和矢状尺寸上的相关性变得更强。在对青春期和成年期的UCLP修复患者进行治疗时，应考虑这些因素。
