PDF(Pubmed)
Abstract：
UNASSIGNED: Dengue infection is spreading worldwide. The clinical spectrum is broad and includes asymptomatic infections. This review provides an overview of the different proportions of asymptomatic infections described in epidemiological studies according to definitions, study designs, and detection methods.
UNASSIGNED: Medline and Embase databases were searched without restriction of date or language. Studies were included if they reported data on the incidence or prevalence of asymptomatic dengue infections. The data were summarized and classified according to the definitions of the term \'asymptomatic\'.
UNASSIGNED: A total of 74 studies were included. The mean proportion of asymptomatic infections among dengue-infected persons was 54% in 50 included studies. The prevalence of dengue infections detected in healthy persons was 0.2% in 24 included studies. The term \'asymptomatic\' has been used to refer to \'clinically undetectable infection\', but also to \'undiagnosed infection\' or \'mild infection\'. Only 8% were clinically undetectable laboratory-confirmed dengue infections.
UNASSIGNED: The proportion of asymptomatic dengue infections varied greatly. Studies proving data on clinically undetectable laboratory-confirmed dengue infections were very few, but provided consistent results of low proportions of asymptomatic infections. These data challenge the assumption that the majority of dengue cases are asymptomatic.
UNASSIGNED: Medline and Embase databases were searched without restriction of date or language. Studies were included if they reported data on the incidence or prevalence of asymptomatic dengue infections. The data were summarized and classified according to the definitions of the term \'asymptomatic\'.
UNASSIGNED: A total of 74 studies were included. The mean proportion of asymptomatic infections among dengue-infected persons was 54% in 50 included studies. The prevalence of dengue infections detected in healthy persons was 0.2% in 24 included studies. The term \'asymptomatic\' has been used to refer to \'clinically undetectable infection\', but also to \'undiagnosed infection\' or \'mild infection\'. Only 8% were clinically undetectable laboratory-confirmed dengue infections.
UNASSIGNED: The proportion of asymptomatic dengue infections varied greatly. Studies proving data on clinically undetectable laboratory-confirmed dengue infections were very few, but provided consistent results of low proportions of asymptomatic infections. These data challenge the assumption that the majority of dengue cases are asymptomatic.
摘要：
■登革热感染正在全球蔓延。临床范围广泛，包括无症状感染。这篇综述概述了流行病学研究中根据定义描述的无症状感染的不同比例，研究设计，和检测方法。
■搜索Medline和Embase数据库，不受日期或语言限制。如果研究报告了无症状登革热感染的发生率或患病率的数据，则包括在内。根据术语“无症状”的定义对数据进行汇总和分类。
■共纳入74项研究。在50项纳入的研究中，登革热感染者中无症状感染的平均比例为54％。在24项纳入的研究中，健康人群中检测到的登革热感染患病率为0.2％。术语“无症状”用于指“临床上无法检测到的感染”，也包括“未诊断的感染”或“轻度感染”。只有8％是临床上无法检测到的实验室确认的登革热感染。
■无症状登革热感染的比例差异很大。关于临床上无法检测到的实验室证实的登革热感染的数据的研究很少，但提供了低比例无症状感染的一致结果。这些数据挑战了大多数登革热病例无症状的假设。
■搜索Medline和Embase数据库，不受日期或语言限制。如果研究报告了无症状登革热感染的发生率或患病率的数据，则包括在内。根据术语“无症状”的定义对数据进行汇总和分类。
■共纳入74项研究。在50项纳入的研究中，登革热感染者中无症状感染的平均比例为54％。在24项纳入的研究中，健康人群中检测到的登革热感染患病率为0.2％。术语“无症状”用于指“临床上无法检测到的感染”，也包括“未诊断的感染”或“轻度感染”。只有8％是临床上无法检测到的实验室确认的登革热感染。
■无症状登革热感染的比例差异很大。关于临床上无法检测到的实验室证实的登革热感染的数据的研究很少，但提供了低比例无症状感染的一致结果。这些数据挑战了大多数登革热病例无症状的假设。
