Abstract：
The main goal of this retrospective study was to examine the morphology of the interthalamic adhesion (ITA) in normal children aged between 1 and 18 years.
The study universe consisted of magnetic resonance images of 180 healthy pediatric subjects (age, 9.50 ± 5.20 years, sex, 90 girls and 90 boys). The cross-sectional area (CSA), vertical diameter (VD), and horizontal diameter (HD) of the ITA were measured and in addition, its location was noted.
HD, VD, and CSA of the ITA were measured as 8.47 ± 1.64 mm, 7.59 ± 1.57 mm, and 52.06 ± 18.51 mm2, respectively. HD did not change from infancy until postpubescence, but then significantly decreased (P < 0.001). VD increased up to early childhood but then did not alter until the end of prepubescence. After that period, it decreased in postpubescence (P < 0.001). CSA tended to decrease in an irregular pattern according to pediatric age periods (P < 0.001). The ITA was located at the anterosuperior quadrant in 138 individuals (76.70%), at the anteroinferior quadrant in 7 individuals (3.90%), and the center of the lateral wall of the third ventricle in 35 individuals (19.40%). Linear functions were calculated as y = 9.490-0.107 × age (years) for HD, y = 8.453-0.091 × age (years) for VD, and y = 63.559-1.211 × age (years) for CSA.
ITA size irregularly decreases with advancing age from 1 to 18 years. Our calculated linear functions, showing the growth dynamics of the ITA by pediatric ages, may be helpful in estimating its dimension.
The study universe consisted of magnetic resonance images of 180 healthy pediatric subjects (age, 9.50 ± 5.20 years, sex, 90 girls and 90 boys). The cross-sectional area (CSA), vertical diameter (VD), and horizontal diameter (HD) of the ITA were measured and in addition, its location was noted.
HD, VD, and CSA of the ITA were measured as 8.47 ± 1.64 mm, 7.59 ± 1.57 mm, and 52.06 ± 18.51 mm2, respectively. HD did not change from infancy until postpubescence, but then significantly decreased (P < 0.001). VD increased up to early childhood but then did not alter until the end of prepubescence. After that period, it decreased in postpubescence (P < 0.001). CSA tended to decrease in an irregular pattern according to pediatric age periods (P < 0.001). The ITA was located at the anterosuperior quadrant in 138 individuals (76.70%), at the anteroinferior quadrant in 7 individuals (3.90%), and the center of the lateral wall of the third ventricle in 35 individuals (19.40%). Linear functions were calculated as y = 9.490-0.107 × age (years) for HD, y = 8.453-0.091 × age (years) for VD, and y = 63.559-1.211 × age (years) for CSA.
ITA size irregularly decreases with advancing age from 1 to 18 years. Our calculated linear functions, showing the growth dynamics of the ITA by pediatric ages, may be helpful in estimating its dimension.
摘要：
目的：这项回顾性研究的主要目的是检查1-18岁正常儿童的丘脑间粘连（ITA）的形态。
方法：研究范围包括180名健康儿科受试者的磁共振图像（年龄：9.50±5.20岁，性别：90个女孩和90个男孩）。横截面积（CSA），测量ITA的垂直（VD）和水平直径（HD），并记录其位置。
结果：HD，ITA的VD和CSA测量为8.47±1.64mm，7.59±1.57mm,分别为52.06±18.51mm2。HD从婴儿期到青春期后都没有改变，但随后显着下降（p<0.001）。VD增加到儿童早期，但是直到青春期结束后才改变。之后,在青春期后下降（p<0.001）。根据儿科年龄，CSA倾向于以不规则的模式降低（p<0.001）。在138名受试者中，ITA位于前上象限(76.70%)，在7名受试者的前下象限(3.90%)，35例（19.40%）位于第三脑室侧壁中心。线性函数计算为y=9.490-0.107xHD的年龄（年），y=8.453-0.091xVD年龄（年），y=63.559-1.211xCSA年龄（年）。
结论：ITA大小随着年龄从1岁增加到18岁而不规则地减小。我们计算的线性函数，按儿科年龄显示ITA的生长动态可能有助于估计其尺寸。
方法：研究范围包括180名健康儿科受试者的磁共振图像（年龄：9.50±5.20岁，性别：90个女孩和90个男孩）。横截面积（CSA），测量ITA的垂直（VD）和水平直径（HD），并记录其位置。
结果：HD，ITA的VD和CSA测量为8.47±1.64mm，7.59±1.57mm,分别为52.06±18.51mm2。HD从婴儿期到青春期后都没有改变，但随后显着下降（p<0.001）。VD增加到儿童早期，但是直到青春期结束后才改变。之后,在青春期后下降（p<0.001）。根据儿科年龄，CSA倾向于以不规则的模式降低（p<0.001）。在138名受试者中，ITA位于前上象限(76.70%)，在7名受试者的前下象限(3.90%)，35例（19.40%）位于第三脑室侧壁中心。线性函数计算为y=9.490-0.107xHD的年龄（年），y=8.453-0.091xVD年龄（年），y=63.559-1.211xCSA年龄（年）。
结论：ITA大小随着年龄从1岁增加到18岁而不规则地减小。我们计算的线性函数，按儿科年龄显示ITA的生长动态可能有助于估计其尺寸。
