Abstract：
COVID-19 may be asymptomatic or have a typical presentation with fever, cough, anosmia, lymphocytopenia. In some cases, it occurs with a \"chimeric\" presentation, with more subtle and ambiguous symptoms which may be initially misdiagnosed and are referred to in long covid condition. A possible central and peripheral nervous system involvement has been recognized. We present our experience and review the literature about association between carpal tunnel syndrome (CTS) and hand\'s arthritis presenting a case series of patients who firmly state that their condition of CTS arised or got worse during a typical presentation of COVID-19. The outbreak of COVID-19 has resulted in significant global healthcare implications. While the respiratory manifestations of COVID-19 have been widely studied, there is emerging evidence suggesting potential associations between COVID-19 and various other health conditions. This review of the literature aims to investigate the potential relationship between COVID-19 and the development or exacerbation of CTS. By synthesizing the available literature on this topic, we aim to provide a comprehensive overview of the current knowledge and enhance our understanding of the potential implications of COVID-19 on CTS. Case series: In this article we report 13 cases of typical presentations of COVID-19 with fever, myalgia, and respiratory system involvement, with a simultaneous aggravation of the median nerve pre-existing neuralgia and some cases that developed a median nerve neuralgia during COVID-19, which came to the attention of the hand surgeon. Some cases had stable symptomatic CTS and were on waiting list for surgical carpal tunnel release, some cases were previously asymptomatic and developed a median nerve neuralgia during COVID-19. All patients referred to a rapid worsening of acral paraesthesia and neuralgic pain of the same quality of CTS and in the median nerve topography. Some patients developed typical COVID-19 symptoms and died; the others were surgically treated. CTS could be an atypical presentations of COVID-19 or a condition of long-covid disease and clinical and epidemiological significance needs to be fully studied. We presented cases of worsening of the median nerve neuralgia which presented among other symptoms of COVID infection. We conclude a causal relation may exist and needs to be further investigated.
摘要：
COVID-19可能无症状或有典型的发热症状，咳嗽,嗅觉缺失,淋巴细胞减少症。在某些情况下,它出现在“嵌合”演示文稿中，具有更微妙和模糊的症状，最初可能会被误诊，并在长期的疾病中被提及。已经认识到可能的中枢和周围神经系统受累。我们介绍了我们的经验，并回顾了有关腕管综合征（CTS）与手关节炎之间关联的文献，这些患者在COVID-19的典型表现中坚定地表示他们的CTS状况出现或恶化。COVID-19的爆发对全球医疗保健产生了重大影响。虽然COVID-19的呼吸道表现已被广泛研究，有新的证据表明COVID-19与其他各种健康状况之间存在潜在关联。这篇文献综述旨在探讨COVID-19与CTS的发展或恶化之间的潜在关系。通过综合有关该主题的现有文献，我们的目标是全面概述当前的知识，并加深我们对COVID-19对CTS的潜在影响的理解。病例系列：在本文中，我们报告了13例典型的COVID-19发热病例，肌痛，和呼吸系统受累，同时加重了正中神经先前存在的神经痛，一些病例在COVID-19期间发展为正中神经痛，这引起了手外科医师的注意。一些病例有稳定症状的CTS，并在等待手术腕管松解术的名单上，一些病例以前无症状，在COVID-19期间出现正中神经痛。所有患者均表示，具有相同质量的CTS和正中神经地形图的肢端感觉异常和神经痛迅速恶化。一些患者出现典型的COVID-19症状并死亡；其他人则接受了手术治疗。CTS可能是COVID-19的非典型表现或长期covid疾病，临床和流行病学意义需要充分研究。我们介绍了正中神经痛恶化的病例，该病例在COVID感染的其他症状中表现出来。我们得出结论，因果关系可能存在，需要进一步研究。
