Abstract:
Cushing\'s syndrome is a condition leading to overproducing of cortisol by the adrenal glands. If the pituitary gland overproduces cortisol, it is called Cushing\'s disease. Cushing\'s syndrome and even Cushing\'s disease during and after pregnancy are rare events. There is not enough literature and guidance for managing and treating these patients. The diagnosis of Cushing\'s syndrome in pregnancy is often delayed because the symptoms overlap. We presented a thin 31-year-old woman, admitted 2 months after a normal-term delivery, with an atypical presentation of Cushing\'s disease, unusual clinical features, and a challenging clinical course. She had no clinical discriminatory features of Cushing\'s syndrome. Given that the patient only presented with psychosis and proximal myopathy and had an uncomplicated pregnancy, our case was considered unusual. The patients also had hyperpigmentation and severe muscle weakness which are among the less common presentations of Cushing\'s syndrome. Our findings suggest that an early diagnosis of Cushing\'s disease is important in pregnancy period for its prevalent fetal and maternal complications, and it should be treated early to optimize fetal and maternal outcomes as there is an increasing trend toward live births in treated participants.
摘要:
库欣综合征是一种导致肾上腺皮质醇过度产生的疾病。如果脑垂体过度分泌皮质醇,它被称为库欣病。库欣综合征,甚至库欣病在怀孕期间和之后都是罕见的事件。没有足够的文献和指导来管理和治疗这些患者。妊娠库欣综合征的诊断通常因症状重叠而延迟。我们介绍了一个31岁的瘦弱女人,正常足月分娩后2个月入院,库欣病的非典型表现,不寻常的临床特征,和具有挑战性的临床课程。她没有库欣综合征的临床辨别特征。鉴于患者仅出现精神病和近端肌病,并且妊娠无并发症,我们的案子被认为是不寻常的.患者还患有色素沉着过度和严重的肌肉无力,这是库欣综合征的较少见表现。我们的研究结果表明,库欣病的早期诊断在妊娠期间对其普遍存在的胎儿和母体并发症很重要。由于接受治疗的参与者有越来越多的活产趋势,因此应及早治疗以优化胎儿和产妇的结局.