PDF(Pubmed)
Abstract：
Multiple endocrine neoplasia type 1 (MEN1) is an inherited endocrine syndrome caused by the mutation in the tumor suppressor gene MEN1. The recurrence rate of primary hyperparathyroidism (PHPT) in patients with MEN1 after parathyroidectomy remains high, and the management of recurrent hyperparathyroidism is still challenging.
We reported a 44-year-old woman with MEN1 combined with PHPT who was diagnosed through genetic screening of the patient and her family members. After parathyroidectomy to remove one parathyroid gland, the patient suffered from persistent high levels of serum calcium and parathyroid hormone, which returned to normal at up to 8 months after ultrasound-guided microwave ablation (MWA) for bilateral parathyroid glands, suggesting an acceptable short-term prognosis.
Ultrasound-guided MWA for parathyroid nodules may be an effective therapeutic strategy for recurrent PHPT in MEN1 patients.
We reported a 44-year-old woman with MEN1 combined with PHPT who was diagnosed through genetic screening of the patient and her family members. After parathyroidectomy to remove one parathyroid gland, the patient suffered from persistent high levels of serum calcium and parathyroid hormone, which returned to normal at up to 8 months after ultrasound-guided microwave ablation (MWA) for bilateral parathyroid glands, suggesting an acceptable short-term prognosis.
Ultrasound-guided MWA for parathyroid nodules may be an effective therapeutic strategy for recurrent PHPT in MEN1 patients.
摘要：
■多发性内分泌瘤1型（MEN1）是一种由肿瘤抑制基因MEN1突变引起的遗传性内分泌综合征。原发性甲状旁腺功能亢进症（PHPT）患者在甲状旁腺切除术后的复发率仍然很高，复发性甲状旁腺功能亢进的治疗仍然具有挑战性。
■我们报道了一名44岁的MEN1合并PHPT的女性，通过对患者及其家人的基因筛查确诊。甲状旁腺切除术后切除一个甲状旁腺，患者血清钙和甲状旁腺激素持续高水平，在超声引导下微波消融（MWA）治疗双侧甲状旁腺8个月后恢复正常，提示可接受的短期预后。
■超声引导下MWA治疗甲状旁腺结节可能是MEN1患者复发性PHPT的有效治疗策略。
■我们报道了一名44岁的MEN1合并PHPT的女性，通过对患者及其家人的基因筛查确诊。甲状旁腺切除术后切除一个甲状旁腺，患者血清钙和甲状旁腺激素持续高水平，在超声引导下微波消融（MWA）治疗双侧甲状旁腺8个月后恢复正常，提示可接受的短期预后。
■超声引导下MWA治疗甲状旁腺结节可能是MEN1患者复发性PHPT的有效治疗策略。
