PDF(Pubmed)
Abstract：
The aim of this study was to compare the intra and postoperative analgesic effects of sacrococcygeal epidural levobupivacaine with those of lumbosacral levobupivacaine in feline ovariohysterectomy. Thirty-six cats were premedicated with intramuscular acepromazine (0.05 mg/kg) and meperidine (6 mg/kg). Anesthesia was induced with intravenous propofol and maintained with isoflurane in oxygen. The cats were randomly assigned one of the three treatments receiving 0.33% levobupivacaine (0.3 mL/kg) into the sacrococcygeal (S-C group, n=12) or lumbosacral (L-S group, n=12) epidural space, or the same volume of 0.9% saline solution into one of the epidural approaches (Control group, n=12). Intraoperatively, cardiorespiratory variables, end-tidal isoflurane concentration (FE´ISO), and fentanyl requirements were recorded. Postoperative pain was assessed by the UNESP (Universidade Estadual Paulista)-Botucatu multidimensional composite pain scale and the Glasgow feline composite measure pain scale up to 8 hr post-extubation. Morphine was administered as rescue analgesia. Overall FE´ISO and fentanyl requirements were lower in the L-S and S-C compared to the Control (P=0.002-0.048, respectively). There was no significant difference in the cardiorespiratory variables during anesthesia, postoperative pain and rescue analgesia among groups. The time to standing after anesthesia was prolonged in the L-S and S-C groups than in the Control (P<0.001). Lumbosacral and sacrococcygeal epidural levobupivacaine resulted in similar decreases in isoflurane requirements and intraoperative fentanyl supplementation in the cats, with no postoperative benefits.
摘要：
这项研究的目的是比较骶尾部硬膜外左布比卡因与腰骶左布比卡因在猫卵巢子宫切除术中的腔内和术后镇痛效果。对36只猫进行了肌内乙酰丙嗪（0.05mg/kg）和哌替啶（6mg/kg）的预治疗。用静脉丙泊酚诱导麻醉，并用异氟烷在氧气中维持麻醉。将接受0.33%左旋布比卡因(0.3mL/kg)的三种治疗方法中的一种随机分配到骶尾部(S-C组,n=12）或腰骶部（L-S组，n=12)硬膜外腔，或将相同体积的0.9％盐溶液注入硬膜外途径之一（对照组，n=12)。术中,心肺变量，潮气末异氟醚浓度（FE'ISO），记录芬太尼需求.术后疼痛通过UNESP（UniversydadeEstadualPaulista）-Botucatu多维复合疼痛量表和格拉斯哥猫科动物复合疼痛量表评估，直至拔管后8小时。吗啡作为抢救镇痛。与对照相比,L-S和S-C中的总FE'ISO和芬太尼要求较低(分别为P=0.002-0.048)。麻醉期间的心肺变量没有显着差异，术后疼痛和抢救镇痛。与对照组相比，L-S组和S-C组麻醉后的站立时间延长（P<0.001）。腰骶部和骶尾部硬膜外左布比卡因导致猫异氟醚需求和术中芬太尼补充相似的减少，没有术后益处。
