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Abstract：
BACKGROUND: Human enterovirus D68 (EV-D68), which belongs to enteroviruses of the small RNA family, is a type of enterovirus that can cause acute respiratory tract infection and central nervous system diseases. This study systematically analysed and summarized EV-D68 antibody studies in databases and identified the seropositivity rates of different regions, ages, and sexes.
METHODS: Meta-analysis was performed using STATA 16.0 software. I2 and Q tests were used to analyse the heterogeneity of the included studies. Meta-regression analysis was performed for different groups, and Egger\'s linear regression analysis was used to evaluate publication bias.
RESULTS: The results of multiple studies indicated that the serological prevalence range of EV-D68 antibody was 17.78-96.69%. The results of the meta-analysis showed that the seropositivity rate of EV-D68 antibody was 76% (95% confidence interval [CI]: 67-84%), among which that of the Chinese population was 74% (95% CI: 61-86%) and that of other countries was 79% (95% CI: 65-91%). At the same time, a subgroup analysis was conducted. The seroprevalence of EV-D68 antibody was related to age but not sex or region.
CONCLUSIONS: The seropositivity rate was lower in the below 5-year age group; however, it gradually increased with age. The results of this study showed that EV-D68 infection was widespread in the population, and the current clinical infection situation could not reflect the actual epidemic situation of the virus, among which children under 5 years old were vulnerable to infection, which should be given greater attention for epidemic prevention and control.
METHODS: Meta-analysis was performed using STATA 16.0 software. I2 and Q tests were used to analyse the heterogeneity of the included studies. Meta-regression analysis was performed for different groups, and Egger\'s linear regression analysis was used to evaluate publication bias.
RESULTS: The results of multiple studies indicated that the serological prevalence range of EV-D68 antibody was 17.78-96.69%. The results of the meta-analysis showed that the seropositivity rate of EV-D68 antibody was 76% (95% confidence interval [CI]: 67-84%), among which that of the Chinese population was 74% (95% CI: 61-86%) and that of other countries was 79% (95% CI: 65-91%). At the same time, a subgroup analysis was conducted. The seroprevalence of EV-D68 antibody was related to age but not sex or region.
CONCLUSIONS: The seropositivity rate was lower in the below 5-year age group; however, it gradually increased with age. The results of this study showed that EV-D68 infection was widespread in the population, and the current clinical infection situation could not reflect the actual epidemic situation of the virus, among which children under 5 years old were vulnerable to infection, which should be given greater attention for epidemic prevention and control.
摘要：
背景：人肠道病毒D68（EV-D68），属于小RNA家族的肠道病毒，是一种肠道病毒，可引起急性呼吸道感染和中枢神经系统疾病。本研究系统分析和总结了数据库中的EV-D68抗体研究，并确定了不同地区的血清阳性率，年龄,和性别。
方法：采用STATA16.0软件进行Meta分析。采用I2和Q检验分析纳入研究的异质性。对不同组进行Meta回归分析,使用Egger的线性回归分析评估发表偏倚。
结果：多项研究结果表明，EV-D68抗体的血清学患病率范围为17.78％-96.69％。Meta分析结果显示,EV-D68抗体阳性检出率为76%(95%CI:67%-84%),其中中国人口为74%(95%CI:61%-86%)，其他国家人口为79%(95%CI:65%-91%)。同时,进行了亚组分析.EV-D68抗体的血清阳性率与年龄有关，而与性别或地区无关。
结论：5岁以下年龄组的血清阳性率较低；然而，随着年龄的增长逐渐增加。这项研究的结果表明，EV-D68感染在人群中普遍存在，目前的临床感染情况不能反映病毒的实际流行情况，其中5岁以下的儿童容易受到感染，应更加重视流行病的预防和控制。
方法：采用STATA16.0软件进行Meta分析。采用I2和Q检验分析纳入研究的异质性。对不同组进行Meta回归分析,使用Egger的线性回归分析评估发表偏倚。
结果：多项研究结果表明，EV-D68抗体的血清学患病率范围为17.78％-96.69％。Meta分析结果显示,EV-D68抗体阳性检出率为76%(95%CI:67%-84%),其中中国人口为74%(95%CI:61%-86%)，其他国家人口为79%(95%CI:65%-91%)。同时,进行了亚组分析.EV-D68抗体的血清阳性率与年龄有关，而与性别或地区无关。
结论：5岁以下年龄组的血清阳性率较低；然而，随着年龄的增长逐渐增加。这项研究的结果表明，EV-D68感染在人群中普遍存在，目前的临床感染情况不能反映病毒的实际流行情况，其中5岁以下的儿童容易受到感染，应更加重视流行病的预防和控制。
