Abstract：
FLOT1, a scaffold protein of lipid rafts, is involved in several biological processes, including lipid raft protein‑-dependent or clathrin‑independent endocytosis, and the formation of hippocampal synapses, amongst others. Increasing evidence has shown that FLOT1 can function as both a cancer promoter and cancer suppressor dependent on the type of cancer. FLOT1 can affect the occurrence and development of several types of cancer by affecting epithelial‑mesenchymal transition, proliferation of cancer cells, and relevant signaling pathways, and is regulated by long intergenic non‑coding RNAs or microRNAs. In the nervous system, overexpression or abnormally low expression of FLOT1 may lead to the occurrence of neurological diseases, such as Alzheimer\'s disease, Parkinson\'s disease, major depressive disorder and other diseases. Additionally, it is also associated with dilated cardiomyopathy, pathogenic microbial infection, diabetes‑related diseases, and gynecological diseases, amongst other diseases. In the present review, the structure and localization of FLOT1, as well as the physiological processes it is involved in are reviewed, and then the upstream and downstream regulation of FLOT1 in human disease, particularly in different types of cancer and neurological diseases are discussed, with a focus on potentially targeting FLOT1 for the clinical treatment of several diseases.
摘要：
脂筏支架蛋白FLOT1,参与了几个生物过程，包括脂筏蛋白依赖性或网格蛋白非依赖性内吞作用，和海马突触的形成，在其他人中。越来越多的证据表明，FLOT1可以作为癌症启动子和癌症抑制剂，这取决于癌症的类型。FLOT1可以通过影响上皮间质转化来影响几种癌症的发生和发展。癌细胞的增殖，和相关的信号通路，并且由长的基因间非编码RNA或microRNA调节。在神经系统中，FLOT1的过度表达或异常低表达可能导致神经系统疾病的发生,如老年痴呆症,帕金森病,抑郁症和其他疾病。此外,它也与扩张型心肌病有关，病原微生物感染，糖尿病相关疾病,和妇科疾病，除了其他疾病。在本次审查中，FLOT1的结构和定位，以及它所涉及的生理过程进行了综述，然后是FLOT1在人类疾病中的上游和下游调节，特别是在不同类型的癌症和神经系统疾病中，重点是可能靶向FLOT1的几种疾病的临床治疗。
