Abstract：
This systematic review study aims to provide comprehensive data on different radiobiological models, parameters, and endpoints used for calculating the normal tissue complication probability (NTCP) based on clinical data from head and neck cancer patients treated with conformal radiotherapy. A systematic literature search was carried out according to the PRISMA guideline for the identification of relevant publications in six electronic databases of Embase, PubMed, Scopus, and Google Scholar to July 2022 using specific keywords in the paper\'s title and abstract. The initial search resulted in 1368 articles for all organs for the review article about the NTCP parameters. One hundred and seventy-eight articles were accepted for all organs with complete parameters for the mentioned models and finally, 20 head and neck cancer articles were accepted for review. Analysis of the studies shows that the Lyman-Kutcher-Burman (LKB) model properly links the NTCP curve parameters to the postradiotherapy endpoints. In the LKB model for esophagus, the minimum, and maximum corresponding parameters were reported as TD50 = 2.61 Gy with grade ≥3 radiation-induced esophagitis endpoints as the minimum TD50 and TD50 = 68 Gy as the maximum ones. nmin = 0.06, nmax = 1.04, mmin = 0.1, and mmax = 0.65, respectively. Unfortunately, there was not a wide range of published articles on other organs at risk like ear or cauda equina except Burman et al. (Fitting of normal tissue tolerance data to an analytic function. Int J Radiat Oncol Biol Phys Ther. 1991;21:123-135). Findings suggest that the validation of different radiobiological models and their corresponding parameters need to be investigated in vivo and in vitro for developing a more accurate NTCP model to be used for radiotherapy treatment planning optimization.
摘要：
这项系统的综述研究旨在提供有关不同放射生物学模型的全面数据，参数,根据接受适形放疗的头颈部癌症患者的临床数据，以及用于计算正常组织并发症概率（NTCP）的终点。根据PRISMA指南对Embase的六个电子数据库中的相关出版物进行了系统的文献检索，PubMed,Scopus,和谷歌学者到2022年7月在论文的标题和摘要中使用特定的关键词。最初的搜索结果是关于NTCP参数的评论文章的所有器官的1368篇文章。一百七十八篇文章被接受的所有器官与完整的参数为上述模型，最后，接受20篇头颈部癌症文章进行审查。对研究的分析表明，Lyman-Kutcher-Burman（LKB）模型将NTCP曲线参数正确地链接到放疗后的终点。在食道的LKB模型中，最低限度,和最大相应参数报告为TD50=2.61Gy，≥3级放射性食管炎终点为最小TD50，TD50=68Gy为最大。nmin=0.06,nmax=1.04,mmin=0.1,mmax=0.65。不幸的是,除Burman等人外，没有发表关于耳朵或马尾神经等其他危险器官的广泛文章。(将正常组织公差数据拟合到分析函数。IntJRadiatOncolBiolPhysTher.1991；21：123-135）。研究结果表明，需要在体内和体外研究不同放射生物学模型及其相应参数的验证，以开发更准确的NTCP模型以用于放射治疗计划优化。
