PDF(Pubmed)
Abstract：
UNASSIGNED: Feline chronic gingivostomatitis (FCGS) is a frequent chronic inflammatory condition in the oral cavity with an etiopathogenesis not completely identified. This study aimed to contribute to the knowledge of FCGS by identifying the presence of feline calicivirus (FCV) antigens and natural killer (NK) cells and comparing them.
UNASSIGNED: Forty biopsies from the oral mucosa of cats diagnosed with chronic gingivostomatitis were subjected to immunohistochemical techniques to evaluate cells with FCV antigens and NK cells positive for CD56.
UNASSIGNED: NK cells were identified in all samples, with an average of 725.3 ± 409.1 cells. Regarding FCV, it was identified in 18 out of 30 samples (60%), with a different number of cells with virus in between the analyzed cases. In all cases, the number of cells infected with FCV was lower than the number of NK cells present in the same samples, but there was no statistical association between them.
UNASSIGNED: This preliminary study shows that NK cells are present in gingivostomatitis lesions not exclusively caused by FCV-stimulus, as only 60% of all cases were positive for this virus, but other antigens should be considered in the etiology of FCGS.
UNASSIGNED: Forty biopsies from the oral mucosa of cats diagnosed with chronic gingivostomatitis were subjected to immunohistochemical techniques to evaluate cells with FCV antigens and NK cells positive for CD56.
UNASSIGNED: NK cells were identified in all samples, with an average of 725.3 ± 409.1 cells. Regarding FCV, it was identified in 18 out of 30 samples (60%), with a different number of cells with virus in between the analyzed cases. In all cases, the number of cells infected with FCV was lower than the number of NK cells present in the same samples, but there was no statistical association between them.
UNASSIGNED: This preliminary study shows that NK cells are present in gingivostomatitis lesions not exclusively caused by FCV-stimulus, as only 60% of all cases were positive for this virus, but other antigens should be considered in the etiology of FCGS.
摘要：
■猫慢性牙龈炎（FCGS）是口腔中常见的慢性炎症，其病因尚未完全确定。这项研究旨在通过确定猫杯状病毒（FCV）抗原和自然杀伤（NK）细胞的存在并进行比较，从而为FCGS的知识做出贡献。
■对诊断为慢性牙龈炎的猫的口腔粘膜进行了40次活检，以进行免疫组织化学技术，以评估具有FCV抗原的细胞和CD56阳性的NK细胞。
■在所有样本中均鉴定出NK细胞，平均725.3±409.1个细胞。关于FCV，它在30个样本中的18个(60%)中被鉴定出来，在分析的病例之间有不同数量的带有病毒的细胞。在所有情况下,感染FCV的细胞数量低于相同样品中存在的NK细胞数量，但它们之间没有统计学关联。
■这项初步研究表明，NK细胞存在于并非完全由FCV刺激引起的牙龈口炎病变中，因为只有60%的病例对这种病毒呈阳性，但在FCGS的病因中应考虑其他抗原。
■对诊断为慢性牙龈炎的猫的口腔粘膜进行了40次活检，以进行免疫组织化学技术，以评估具有FCV抗原的细胞和CD56阳性的NK细胞。
■在所有样本中均鉴定出NK细胞，平均725.3±409.1个细胞。关于FCV，它在30个样本中的18个(60%)中被鉴定出来，在分析的病例之间有不同数量的带有病毒的细胞。在所有情况下,感染FCV的细胞数量低于相同样品中存在的NK细胞数量，但它们之间没有统计学关联。
■这项初步研究表明，NK细胞存在于并非完全由FCV刺激引起的牙龈口炎病变中，因为只有60%的病例对这种病毒呈阳性，但在FCGS的病因中应考虑其他抗原。
