PDF(Pubmed)
Abstract：
HPV has been linked to the development of precancerous and cancerous lesions. The aim of this study was to evaluate the burden of HPV-related hospitalization in Germany from 2000 to 2021 and the potential impact of the COVID-19 pandemic on it.
We performed a retrospective query using data from the German Statistical Office from 2000 to 2021, including hospital admission, inpatient mortality and hospital stay length data on cervical cancer/dysplasia, female genitourinary tract, anal, penile, head and neck cancers.
The HPV-attributable hospitalization rate per 100,000 inhabitants in Germany has decreased over time, from 89 cases in 2000 to 60 in 2021, with an average annual percent change (AAPC) of -1.93 (CI -2.08--1.79, p < 0.05). The same trend was observed for the average hospital stay, which declined from 9 to 7 days, with an AAPC of -1.33 (CI -1.52--1.21, p < 0.05). An undulating but overall slightly declining pattern was observed for the inpatient mortality (AAPC -0.92, CI -1.21--0.64, p < 0.05). We observed a reduction in the hospitalization rates for invasive and non-invasive cervical cancer, which was observed in almost all age groups and in all German federal states.
Our study provides a comprehensive analysis of the trends in HPV-related hospitalizations over the past two decades. The decline in hospitalization rates for cervical cancer and dysplasia suggests the potential efficacy of the HPV vaccination and screening programs.
We performed a retrospective query using data from the German Statistical Office from 2000 to 2021, including hospital admission, inpatient mortality and hospital stay length data on cervical cancer/dysplasia, female genitourinary tract, anal, penile, head and neck cancers.
The HPV-attributable hospitalization rate per 100,000 inhabitants in Germany has decreased over time, from 89 cases in 2000 to 60 in 2021, with an average annual percent change (AAPC) of -1.93 (CI -2.08--1.79, p < 0.05). The same trend was observed for the average hospital stay, which declined from 9 to 7 days, with an AAPC of -1.33 (CI -1.52--1.21, p < 0.05). An undulating but overall slightly declining pattern was observed for the inpatient mortality (AAPC -0.92, CI -1.21--0.64, p < 0.05). We observed a reduction in the hospitalization rates for invasive and non-invasive cervical cancer, which was observed in almost all age groups and in all German federal states.
Our study provides a comprehensive analysis of the trends in HPV-related hospitalizations over the past two decades. The decline in hospitalization rates for cervical cancer and dysplasia suggests the potential efficacy of the HPV vaccination and screening programs.
摘要：
HPV与癌前病变和癌变的发展有关。这项研究的目的是评估2000年至2021年德国HPV相关住院的负担以及COVID-19大流行对其的潜在影响。
方法：我们使用德国统计局从2000年到2021年的数据进行了回顾性查询，包括住院，宫颈癌/异型增生的住院死亡率和住院时间数据，女性泌尿生殖道，肛门,阴茎,头颈癌.
结果：随着时间的推移，德国每10万居民的HPV归因住院率有所下降，从2000年的89例到2021年的60例，平均年变化百分比（AAPC）为-1.93（CI-2.08--1.79，p<0.05）。平均住院时间也有同样的趋势,从9天下降到7天，AAPC为-1.33（CI-1.52--1.21，p<0.05）。观察到住院患者死亡率呈起伏但总体略有下降的模式(AAPC-0.92,CI-1.21--0.64,p<0.05)。我们观察到浸润性和非浸润性宫颈癌的住院率降低，在几乎所有年龄组和所有德国联邦州都观察到了这一点。
结论：我们的研究提供了过去20年HPV相关住院趋势的综合分析。宫颈癌和异型增生的住院率下降表明HPV疫苗接种和筛查计划的潜在功效。
方法：我们使用德国统计局从2000年到2021年的数据进行了回顾性查询，包括住院，宫颈癌/异型增生的住院死亡率和住院时间数据，女性泌尿生殖道，肛门,阴茎,头颈癌.
结果：随着时间的推移，德国每10万居民的HPV归因住院率有所下降，从2000年的89例到2021年的60例，平均年变化百分比（AAPC）为-1.93（CI-2.08--1.79，p<0.05）。平均住院时间也有同样的趋势,从9天下降到7天，AAPC为-1.33（CI-1.52--1.21，p<0.05）。观察到住院患者死亡率呈起伏但总体略有下降的模式(AAPC-0.92,CI-1.21--0.64,p<0.05)。我们观察到浸润性和非浸润性宫颈癌的住院率降低，在几乎所有年龄组和所有德国联邦州都观察到了这一点。
结论：我们的研究提供了过去20年HPV相关住院趋势的综合分析。宫颈癌和异型增生的住院率下降表明HPV疫苗接种和筛查计划的潜在功效。
