PDF(Pubmed)
Abstract：
Dengue fever has been a public health problem in the Caribbean region since 1981, when it first reappeared in Cuba. In 1989, it was reported in Martinique and Guadeloupe (two French islands 200 km apart); since then, DENV has caused several epidemics locally. In 2019-2021, DENV-1, DENV-2, and DENV-3 were detected. Serotype distribution was differentiated, with DENV-2 and DENV-3 predominating in Guadeloupe and Martinique, respectively. Complete genome sequencing was carried out on 32 specimens, and phylogenic analysis identified the circulation of genotype V for DENV-1, cosmopolitan genotype for DENV-2, and genotype III for DENV-3. However, two distinct circulating groups were identified for DENV-1 and DENV-3, suggesting independent introductions. Overall, despite the context of the COVID-19 pandemic and the associated travel restrictions, these results confirm the active circulation of DENV and specific epidemiological features on each of the two islands. Such differences may be linked to the founder effect of the various introduction events, and to local factors such as the population immunity and the transmission capacity of the vectors. Further genomic and epidemiological characterization of DENV strains remains essential to understand how dengue spreads in each specific geographical context and to prevent future epidemics.
摘要：
自1981年首次在古巴再次出现登革热以来，登革热一直是加勒比地区的公共卫生问题。1989年，据报道在马提尼克岛和瓜德罗普岛（两个相距200公里的法国岛屿）；从那以后，DENV在当地引起了几次流行病。在2019-2021年，检测到DENV-1，DENV-2和DENV-3。血清型分布是有区别的，DENV-2和DENV-3在瓜德罗普岛和马提尼克岛占主导地位，分别。对32个标本进行了全基因组测序,和系统发育分析确定了DENV-1的基因型V，DENV-2的世界性基因型和DENV-3的基因型III的循环。然而,对于DENV-1和DENV-3,确定了两个不同的循环组,建议进行独立的导入.总的来说,尽管在COVID-19大流行和相关的旅行限制的背景下，这些结果证实了DENV的活跃循环和两个岛屿上的特定流行病学特征。这种差异可能与各种介绍活动的创始人效应有关，以及人口免疫和媒介传播能力等局部因素。DENV毒株的进一步基因组和流行病学特征对于了解登革热如何在每个特定的地理环境中传播和预防未来的流行仍然至关重要。
