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Abstract：
The functionalization of AuNPs with different biological elements was achieved to investigate their possibility in biomedical applications such as drug delivery, vaccine development, sensing, and imaging. Biofunctionalized AuNPs are pursued for applications such as drug delivery, vaccine development, sensing, and imaging. In this study, AuNPs with diameters of 20 nm were functionalized with lipoic acid, mannose, or the cRGD peptide. By using UV-vis spectroscopy, Fourier transform infrared spectroscopy, dynamic light scattering, transmission electron microscopy, and scanning tunneling microscopy techniques, we showed that AuNPs can be functionalized by these biomolecules in a reliable way to obtain conjugates to explore potential biomedical applications. In particular, we demonstrate that the STM technique can be employed to analyze biofunctionalized AuNPs, and the obtained information can be valuable in the design of biomedical applications.
摘要：
AuNP与不同的生物元素的官能化被实现，以研究它们在生物医学应用中的可能性，如药物递送，疫苗开发,传感,和成像。生物功能化的AuNP被用于药物递送等应用，疫苗开发,传感,和成像。在这项研究中,直径为20nm的AuNP用硫辛酸官能化，甘露糖,或cRGD肽。通过使用紫外-可见光谱，傅里叶变换红外光谱,动态光散射,透射电子显微镜,和扫描隧道显微镜技术，我们表明AuNPs可以被这些生物分子以可靠的方式功能化以获得缀合物，以探索潜在的生物医学应用。特别是,我们证明了STM技术可以用来分析生物功能化的AuNPs，并且获得的信息在生物医学应用的设计中可能是有价值的。
