METHODS: Between January 2008 and October 2020, 45 patients underwent CKFRT for cerebral AVMs as a first treatment. The delineation of AVM targets included AVM nidus. The mean target volume was 4.07 cm3, and 9 lesions (20%) were larger than 10.0 cm3. The mean marginal dose was 24 Gy (range, 20-35 Gy). CKFRT was delivered in median 3 fractions (range, 2 ∼ 5 fractions). AVM obliteration following CKFRT was confirmed by magnetic resonance imaging or angiography.
RESULTS: During a median follow-up of 47 (5-148) months, complete obliteration and partial obliteration of AVM after CKFRT were obtained in 23 (51%) and 13 (29%) patients, respectively. Median time to complete obliteration was 39 (15-63) months. The cumulative probability of complete obliteration rate at 3 years was 47%. Complete obliteration rate of AVM was associated with Radiosurgery-based AVM score, which was consisted of AVM volume, patients age, and AVM location. One (2%) patient had hemorrhage during the follow-up period.
CONCLUSIONS: CKFRT is an effective primary treatment for patients with cerebral AVMs with a low hemorrhage risk.
方法:在2008年1月至2020年10月之间,45例患者接受了CKFRT治疗,作为首次治疗。AVM目标的划定包括AVMnidus。平均目标体积为4.07cm3,9个病变(20%)大于10.0cm3。平均边缘剂量为24Gy(范围,20-35Gy)。CKFRT的中位数为3分(范围,2-5分)。通过磁共振成像或血管造影证实CKFRT后的AVM闭塞。
结果:在47(5-148)个月的中位随访期间,在23例(51%)和13例(29%)患者中,CKFRT后AVM完全消失和部分消失,分别。完成闭塞的中位时间为39(15-63)个月。3年完全消失率的累积概率为47%。AVM的完全消失率与基于放射外科的AVM评分相关,它由AVM卷组成,患者年龄,和AVM位置。1例(2%)患者在随访期间出现出血。
结论:CKFRT是低出血风险的脑AVM患者的有效主要治疗方法。