PDF(Pubmed)
Abstract：
A 20-month-old girl was diagnosed with Guillain - Barré syndrome (GBS) based on progressive muscle weakness, areflexia, and albuminocytologic dissociation of the cerebrospinal fluid. Despite timely and systematic treatment, she eventually became paralyzed. There is a temporal correlation between the girl\'s GBS and the DTaP vaccination, but the exact causal relationship between the two is still debatable. Furthermore, we summarized clinical features of other 45 published GBS cases after DTP vaccines (or vaccine substances containing tetanus) through a systematic review. The mean onset age, sex distribution, onset time after vaccination, detection of antiganglioside antibodies, and other basic clinical features of GBS after DTP vaccination (or vaccine substances containing tetanus) were analyzed. The temporal pattern of GBS after vaccination was similar to that of GBS after infection. Herein, we report this rare case of presumptive pediatric GBS after DTaP vaccination and review similar cases to draw the attention of medical personnel to similar events after vaccination. An association between DTP vaccines and GBS has been proposed, and the causal relationship between these two incidents are worthy further exploration. Moreover, surveillance and vigilance for GBS after vaccination are highly recommended.
摘要：
一名20个月大的女孩因进行性肌肉无力被诊断为格林-巴利综合征（GBS），无反射,和脑脊液的白蛋白细胞解离。尽管及时和系统的治疗，她最终瘫痪了。女孩的GBS和DTaP疫苗接种之间存在时间相关性，但是两者之间的确切因果关系仍然存在争议。此外，我们通过系统评价,总结了其他45例发表的DTP疫苗(或含破伤风的疫苗物质)后GBS病例的临床特征.平均发病年龄，性别分布，接种疫苗后的发病时间，检测抗神经节苷脂抗体，并分析了DTP疫苗（或含破伤风的疫苗物质）接种后GBS的其他基本临床特征。疫苗接种后GBS的时间模式与感染后GBS的时间模式相似。在这里，我们报告了这种罕见的DTaP疫苗接种后推定儿科GBS病例,并回顾了类似病例,以提请医务人员注意疫苗接种后的类似事件.已经提出了DTP疫苗和GBS之间的关联，这两个事件之间的因果关系值得进一步探讨。此外，强烈建议在接种疫苗后对GBS进行监测和警惕.
