PDF(Pubmed)
Abstract：
BACKGROUND: Polynucleotides (PN) are increasingly used for the treatment of facial erythema in the Republic of Korea. However, there are limited pre-clinical and clinical data on the efficacy of polynucleotides for facial erythema. In this study, we investigated the current practice and perceived effectiveness of polynucleotide treatment for facial erythema among cosmetic physicians.
METHODS: By conducting a survey among clinicians who use PN in clinical practice, we explored the current practices and assessed the perceived effectiveness of polynucleotides in treating facial erythema.
RESULTS: A total of 557 physicians who used polynucleotides for facial erythema participated in the survey. Polynucleotides were used by 84.4%, 66.4%, and 47.4% of physicians for facial erythema caused by inflammatory facial dermatosis, repeated laser/microneedle radiofrequency, and steroid overuse, respectively. Among those users, 88.1%, 90%, and 83.7% respectively in those same categories answered that polynucleotides were \"highly effective\" or \"effective.\" Furthermore, they agreed that polynucleotides have the following properties: wound healing/regeneration (95.8%), protection of skin barrier (92.2%), hydration (90.5%), vascular stabilization (81.0%), and anti-inflammation (79.5%).
CONCLUSIONS: Our findings showed that cosmetic physicians in the Republic of Korea have used PN as a part of combination treatment for facial erythema resulting from inflammatory facial dermatosis and repeated laser/ microneedle radiofrequency, rather than from steroid overuse. Also, most clinicians agreed that PN was effective for treatment of facial erythema. Given the lack of pre-clinical and clinical trial evidence, the empirical responses of practicing physicians provide useful information to guide clinical practice and further research.
METHODS: By conducting a survey among clinicians who use PN in clinical practice, we explored the current practices and assessed the perceived effectiveness of polynucleotides in treating facial erythema.
RESULTS: A total of 557 physicians who used polynucleotides for facial erythema participated in the survey. Polynucleotides were used by 84.4%, 66.4%, and 47.4% of physicians for facial erythema caused by inflammatory facial dermatosis, repeated laser/microneedle radiofrequency, and steroid overuse, respectively. Among those users, 88.1%, 90%, and 83.7% respectively in those same categories answered that polynucleotides were \"highly effective\" or \"effective.\" Furthermore, they agreed that polynucleotides have the following properties: wound healing/regeneration (95.8%), protection of skin barrier (92.2%), hydration (90.5%), vascular stabilization (81.0%), and anti-inflammation (79.5%).
CONCLUSIONS: Our findings showed that cosmetic physicians in the Republic of Korea have used PN as a part of combination treatment for facial erythema resulting from inflammatory facial dermatosis and repeated laser/ microneedle radiofrequency, rather than from steroid overuse. Also, most clinicians agreed that PN was effective for treatment of facial erythema. Given the lack of pre-clinical and clinical trial evidence, the empirical responses of practicing physicians provide useful information to guide clinical practice and further research.
摘要：
背景：在大韩民国，多核苷酸（PN）越来越多地用于治疗面部红斑。然而,关于多核苷酸对面部红斑的疗效的临床前和临床数据有限.在这项研究中,我们调查了目前的实践和美容医师对多核苷酸治疗面部红斑的有效性。
方法：通过对临床实践中使用PN的临床医生进行调查，我们探索了目前的实践，并评估了多核苷酸治疗面部红斑的有效性。
结果：共有557名使用多核苷酸治疗面部红斑的医生参与了调查。多核苷酸的使用率为84.4%，66.4%,和47.4%的医生为由炎症性面部皮肤病引起的面部红斑，重复激光/微针射频，和类固醇的过度使用，分别。在这些用户中，88.1%,90%,在这些类别中，分别有83.7%的人回答说多核苷酸是“高效”或“有效”。\"此外，他们同意多核苷酸具有以下特性：伤口愈合/再生（95.8％），保护皮肤屏障（92.2%），水合作用（90.5%），血管稳定（81.0%），和抗炎（79.5%）。
结论：我们的发现表明，大韩民国的美容医生已将PN用作因炎性面部皮肤病和反复激光/微针射频引起的面部红斑的联合治疗的一部分，而不是类固醇的过度使用。此外，大多数临床医生认为PN治疗面部红斑有效.鉴于缺乏临床前和临床试验证据，执业医师的经验反应为指导临床实践和进一步研究提供了有用的信息。
方法：通过对临床实践中使用PN的临床医生进行调查，我们探索了目前的实践，并评估了多核苷酸治疗面部红斑的有效性。
结果：共有557名使用多核苷酸治疗面部红斑的医生参与了调查。多核苷酸的使用率为84.4%，66.4%,和47.4%的医生为由炎症性面部皮肤病引起的面部红斑，重复激光/微针射频，和类固醇的过度使用，分别。在这些用户中，88.1%,90%,在这些类别中，分别有83.7%的人回答说多核苷酸是“高效”或“有效”。\"此外，他们同意多核苷酸具有以下特性：伤口愈合/再生（95.8％），保护皮肤屏障（92.2%），水合作用（90.5%），血管稳定（81.0%），和抗炎（79.5%）。
结论：我们的发现表明，大韩民国的美容医生已将PN用作因炎性面部皮肤病和反复激光/微针射频引起的面部红斑的联合治疗的一部分，而不是类固醇的过度使用。此外，大多数临床医生认为PN治疗面部红斑有效.鉴于缺乏临床前和临床试验证据，执业医师的经验反应为指导临床实践和进一步研究提供了有用的信息。
