PDF(Pubmed)
Abstract：
UNASSIGNED: Metabolic syndrome (MetS) is a well-known noncommunicable disease that plays a significant role in emerging other chronic disorders and following complications. MetS is also involved in the pathophysiology of numerous dermatological diseases. We aim to evaluate the association of MetS with the most prevalent dermatological diseases.
UNASSIGNED: A systematic search was carried out on PubMed, Science Direct, Web of Science, Cochrane, as well as the Google Scholar search engine. Only English case-control studies regarding MetS and any skin disease from the beginning of 2010 up to November 15, 2022, were selected. The study was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA).
UNASSIGNED: A total of 37 studies (13,830 participants) met the inclusion criteria. According to our result, patients with psoriasis, hidradenitis suppurativa (HS), vitiligo, androgenetic alopecia (AGA), and lichen planus (LP) have a higher chance of having MetS compared to the general population. Furthermore, people with seborrheic dermatitis (SED) and rosacea are more prone to insulin resistance, high blood pressure (BP), and higher blood lipids. After pooling data, the meta-analysis revealed a significant association between MetS and skin diseases (pooled odds ratio [OR]: 3.28, 95% confidence interval: 2.62-4.10). Concerning the type of disease, MetS has been correlated with AGA (OR: 11.86), HS (OR: 4.46), LP (OR: 3.79), and SED (OR: 2.45). Psoriasis also showed a significant association but with high heterogeneity (OR: 2.89). Moreover, skin diseases and MetS are strongly associated in Spain (OR: 5.25) and Thailand (OR: 11.86). Regarding the metaregression model, the effect size was reduced with increasing age (OR: 0.965), while the size increased with AGA (OR: 3.064).
UNASSIGNED: MetS is closely associated with skin complications. Dermatologists and other multidisciplinary teams should be cautious while treating these patients to prevent severe complications resulting from MetS.
UNASSIGNED: A systematic search was carried out on PubMed, Science Direct, Web of Science, Cochrane, as well as the Google Scholar search engine. Only English case-control studies regarding MetS and any skin disease from the beginning of 2010 up to November 15, 2022, were selected. The study was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA).
UNASSIGNED: A total of 37 studies (13,830 participants) met the inclusion criteria. According to our result, patients with psoriasis, hidradenitis suppurativa (HS), vitiligo, androgenetic alopecia (AGA), and lichen planus (LP) have a higher chance of having MetS compared to the general population. Furthermore, people with seborrheic dermatitis (SED) and rosacea are more prone to insulin resistance, high blood pressure (BP), and higher blood lipids. After pooling data, the meta-analysis revealed a significant association between MetS and skin diseases (pooled odds ratio [OR]: 3.28, 95% confidence interval: 2.62-4.10). Concerning the type of disease, MetS has been correlated with AGA (OR: 11.86), HS (OR: 4.46), LP (OR: 3.79), and SED (OR: 2.45). Psoriasis also showed a significant association but with high heterogeneity (OR: 2.89). Moreover, skin diseases and MetS are strongly associated in Spain (OR: 5.25) and Thailand (OR: 11.86). Regarding the metaregression model, the effect size was reduced with increasing age (OR: 0.965), while the size increased with AGA (OR: 3.064).
UNASSIGNED: MetS is closely associated with skin complications. Dermatologists and other multidisciplinary teams should be cautious while treating these patients to prevent severe complications resulting from MetS.
摘要：
■代谢综合征（MetS）是一种众所周知的非传染性疾病，在其他慢性疾病和并发症的出现中起着重要作用。MetS还涉及许多皮肤病的病理生理学。我们旨在评估MetS与最常见的皮肤病的关联。
■在PubMed上进行了系统搜索，科学直接，WebofScience,科克伦,以及谷歌学者搜索引擎。仅选择了从2010年初到2022年11月15日的有关MetS和任何皮肤病的英语病例对照研究。本研究基于系统评价和荟萃分析（PRISMA）的首选报告项目进行。
■共有37项研究（13,830名参与者）符合纳入标准。根据我们的结果,牛皮癣患者，化脓性汗腺炎（HS），白癜风,雄激素性脱发（AGA），与普通人群相比，扁平苔藓（LP）发生MetS的机会更高。此外，脂溢性皮炎（SED）和酒渣鼻患者更容易出现胰岛素抵抗，高血压（BP），和更高的血脂。汇集数据后，荟萃分析显示,MetS与皮肤病之间存在显著关联(合并比值比[OR]:3.28,95%置信区间:2.62~4.10).关于疾病的类型，MetS与AGA相关(OR：11.86)，HS(OR:4.46),LP（OR：3.79），和SED（或：2.45）。银屑病也显示出显着相关性，但具有高度异质性（OR：2.89）。此外，在西班牙(OR:5.25)和泰国(OR:11.86),皮肤病和代谢综合征密切相关。关于回归模型，效应大小随着年龄的增加而减小（OR：0.965），而大小随AGA增加（OR：3.064）。
■MetS与皮肤并发症密切相关。皮肤科医生和其他多学科团队在治疗这些患者时应谨慎，以防止由MetS引起的严重并发症。
■在PubMed上进行了系统搜索，科学直接，WebofScience,科克伦,以及谷歌学者搜索引擎。仅选择了从2010年初到2022年11月15日的有关MetS和任何皮肤病的英语病例对照研究。本研究基于系统评价和荟萃分析（PRISMA）的首选报告项目进行。
■共有37项研究（13,830名参与者）符合纳入标准。根据我们的结果,牛皮癣患者，化脓性汗腺炎（HS），白癜风,雄激素性脱发（AGA），与普通人群相比，扁平苔藓（LP）发生MetS的机会更高。此外，脂溢性皮炎（SED）和酒渣鼻患者更容易出现胰岛素抵抗，高血压（BP），和更高的血脂。汇集数据后，荟萃分析显示,MetS与皮肤病之间存在显著关联(合并比值比[OR]:3.28,95%置信区间:2.62~4.10).关于疾病的类型，MetS与AGA相关(OR：11.86)，HS(OR:4.46),LP（OR：3.79），和SED（或：2.45）。银屑病也显示出显着相关性，但具有高度异质性（OR：2.89）。此外，在西班牙(OR:5.25)和泰国(OR:11.86),皮肤病和代谢综合征密切相关。关于回归模型，效应大小随着年龄的增加而减小（OR：0.965），而大小随AGA增加（OR：3.064）。
■MetS与皮肤并发症密切相关。皮肤科医生和其他多学科团队在治疗这些患者时应谨慎，以防止由MetS引起的严重并发症。
