PDF(Pubmed)
Abstract：
Severe community-acquired pneumonia (sCAP) is life-threatening and characterized by intensive care unit (ICU) admission and high mortality. And they are vulnerable to hospital-acquired infection. In such a severe condition, metagenomic next-generation sequencing (mNGS) outperforms for short turnaround time and broad detection spectrum.
A 15-year-old male with severe influenza and methicillin-resistant Staphylococcus aureus (MRSA) pneumonia progressed rapidly, initially misdiagnosed as influenza co-infected with Aspergillus for misleading bronchoscopy manifestations. The turnaround time of mNGS is 13 h, which has the potential to expedite the clinical medication process. With the powerful support of mNGS and extracorporeal membrane oxygenation (ECMO), anti-infective therapy was adjusted accordingly, and vital signs gradually stabilized. After tortuous treatment and unremitting efforts, the patient recovered well.
Rapid mNGS applications, timely medication adjustments, strong ECMO support and active family compliance contribute to this miracle of life. False-negative or false-positive results are alarming, anti-infective medications should be adjusted after a comprehensive review of physical status and other indicators.
A 15-year-old male with severe influenza and methicillin-resistant Staphylococcus aureus (MRSA) pneumonia progressed rapidly, initially misdiagnosed as influenza co-infected with Aspergillus for misleading bronchoscopy manifestations. The turnaround time of mNGS is 13 h, which has the potential to expedite the clinical medication process. With the powerful support of mNGS and extracorporeal membrane oxygenation (ECMO), anti-infective therapy was adjusted accordingly, and vital signs gradually stabilized. After tortuous treatment and unremitting efforts, the patient recovered well.
Rapid mNGS applications, timely medication adjustments, strong ECMO support and active family compliance contribute to this miracle of life. False-negative or false-positive results are alarming, anti-infective medications should be adjusted after a comprehensive review of physical status and other indicators.
摘要：
■严重的社区获得性肺炎（sCAP）危及生命，其特征是重症监护病房（ICU）入院和高死亡率。他们容易受到医院获得性感染。在如此严重的情况下，宏基因组下一代测序（mNGS）优于短周转时间和宽检测谱。
一名患有严重流感和耐甲氧西林金黄色葡萄球菌（MRSA）肺炎的15岁男性迅速进展，最初误诊为流感与曲霉菌共感染，误导支气管镜检查表现。mNGS的周转时间为13小时，这有可能加快临床用药过程。在mNGS和体外膜氧合（ECMO）的有力支持下，抗感染治疗进行了相应调整，生命体征逐渐稳定。经过曲折的治疗和不懈的努力，病人恢复得很好。
■快速mNGS应用程序，及时调整用药,强大的ECMO支持和积极的家庭合规有助于这一生命奇迹。假阴性或假阳性结果令人震惊，抗感染药物应在全面检查身体状况和其他指标后进行调整.
一名患有严重流感和耐甲氧西林金黄色葡萄球菌（MRSA）肺炎的15岁男性迅速进展，最初误诊为流感与曲霉菌共感染，误导支气管镜检查表现。mNGS的周转时间为13小时，这有可能加快临床用药过程。在mNGS和体外膜氧合（ECMO）的有力支持下，抗感染治疗进行了相应调整，生命体征逐渐稳定。经过曲折的治疗和不懈的努力，病人恢复得很好。
■快速mNGS应用程序，及时调整用药,强大的ECMO支持和积极的家庭合规有助于这一生命奇迹。假阴性或假阳性结果令人震惊，抗感染药物应在全面检查身体状况和其他指标后进行调整.
