Abstract：
OBJECTIVE: The goal of this systematic review was to examine the current literature on the urinary microbiome and its associations with noninfectious, nonmalignant, urologic diseases. Secondarily, we aimed to describe the most common bioinformatics used to analyze the urinary microbiome.
METHODS: A comprehensive literature search of Ovid MEDLINE using the keywords \"microbiota\" AND \"prostatic hyperplasia,\" \"microbiota\" AND \"urinary bladder, overactive,\" \"microbiota\" AND \"pelvic pain,\" and \"microbiota\" AND \"urolithiasis\" OR \"nephrolithiasis\" OR \"urinary calculi\" AND \"calcium oxalate\" was performed to identify relevant clinical microbiome studies associated with noninfectious benign urological conditions published from 2010 to 2022. We included human studies that evaluated the urinary, stone, or semen microbiota, or any combination of the above-mentioned locations.
RESULTS: A total of 25 human studies met the inclusion criteria: 4 on benign prostatic hyperplasia (BPH), 9 on overactive bladder (OAB), 8 on calcium oxalate stones, and 4 on chronic pelvic pain syndrome (CPPS). Specific taxonomic profiles in the urine microbiome were associated with each pathology, and evaluation of alpha- and beta-diversity and relative abundance was accounted for most of the studies. Symptom prevalence and severity were also analyzed and showed associations with specific microbes.
CONCLUSIONS: The study of the urogenital microbiome is rapidly expanding in urology. Noninfectious benign urogenital diseases, such as BPH, calcium oxalate stones, CPPS, and OAB were found to be associated with specific microbial taxonomies. Further research with larger study populations is necessary to solidify the knowledge of the urine microbiome in these conditions and to facilitate the creation of microbiome-based diagnostic and therapeutic approaches.
METHODS: A comprehensive literature search of Ovid MEDLINE using the keywords \"microbiota\" AND \"prostatic hyperplasia,\" \"microbiota\" AND \"urinary bladder, overactive,\" \"microbiota\" AND \"pelvic pain,\" and \"microbiota\" AND \"urolithiasis\" OR \"nephrolithiasis\" OR \"urinary calculi\" AND \"calcium oxalate\" was performed to identify relevant clinical microbiome studies associated with noninfectious benign urological conditions published from 2010 to 2022. We included human studies that evaluated the urinary, stone, or semen microbiota, or any combination of the above-mentioned locations.
RESULTS: A total of 25 human studies met the inclusion criteria: 4 on benign prostatic hyperplasia (BPH), 9 on overactive bladder (OAB), 8 on calcium oxalate stones, and 4 on chronic pelvic pain syndrome (CPPS). Specific taxonomic profiles in the urine microbiome were associated with each pathology, and evaluation of alpha- and beta-diversity and relative abundance was accounted for most of the studies. Symptom prevalence and severity were also analyzed and showed associations with specific microbes.
CONCLUSIONS: The study of the urogenital microbiome is rapidly expanding in urology. Noninfectious benign urogenital diseases, such as BPH, calcium oxalate stones, CPPS, and OAB were found to be associated with specific microbial taxonomies. Further research with larger study populations is necessary to solidify the knowledge of the urine microbiome in these conditions and to facilitate the creation of microbiome-based diagnostic and therapeutic approaches.
摘要：
目的：本系统综述的目的是检查当前文献中关于尿液微生物组及其与非感染性疾病的关系，非恶性,泌尿系疾病.其次，我们旨在描述用于分析尿液微生物组的最常见的生物信息学。
方法：使用关键词“微生物群”和“前列腺增生”对OvidMEDLINE进行全面文献检索，\"\"微生物群\"和\"膀胱，过度活跃,\"\"微生物群\"和\"骨盆疼痛,进行了“”和“微生物群”和“尿石症”或“肾结石”或“尿石症”和“草酸钙”，以确定与非感染性良性泌尿疾病相关的相关临床微生物组研究从2010年到2022年发表。我们纳入了评估泌尿系统的人体研究，石头,或精液微生物群，或上述位置的任何组合。
结果：共有25项人体研究符合纳入标准：4项关于良性前列腺增生（BPH），9膀胱过度活动症（OAB），8草酸钙结石，4慢性盆腔疼痛综合征（CPPS）。尿液微生物组中的特定分类学特征与每种病理有关，对α-和β-多样性和相对丰度的评估占了大多数研究。还分析了症状患病率和严重程度，并显示出与特定微生物的关联。
结论：泌尿生殖道微生物组的研究在泌尿外科中迅速扩展。非感染性良性泌尿生殖道疾病,如BPH,草酸钙结石,CPPS,和OAB被发现与特定的微生物分类有关。有必要对更大的研究人群进行进一步的研究，以巩固这些条件下尿液微生物组的知识，并促进基于微生物组的诊断和治疗方法的创建。
方法：使用关键词“微生物群”和“前列腺增生”对OvidMEDLINE进行全面文献检索，\"\"微生物群\"和\"膀胱，过度活跃,\"\"微生物群\"和\"骨盆疼痛,进行了“”和“微生物群”和“尿石症”或“肾结石”或“尿石症”和“草酸钙”，以确定与非感染性良性泌尿疾病相关的相关临床微生物组研究从2010年到2022年发表。我们纳入了评估泌尿系统的人体研究，石头,或精液微生物群，或上述位置的任何组合。
结果：共有25项人体研究符合纳入标准：4项关于良性前列腺增生（BPH），9膀胱过度活动症（OAB），8草酸钙结石，4慢性盆腔疼痛综合征（CPPS）。尿液微生物组中的特定分类学特征与每种病理有关，对α-和β-多样性和相对丰度的评估占了大多数研究。还分析了症状患病率和严重程度，并显示出与特定微生物的关联。
结论：泌尿生殖道微生物组的研究在泌尿外科中迅速扩展。非感染性良性泌尿生殖道疾病,如BPH,草酸钙结石,CPPS,和OAB被发现与特定的微生物分类有关。有必要对更大的研究人群进行进一步的研究，以巩固这些条件下尿液微生物组的知识，并促进基于微生物组的诊断和治疗方法的创建。
