Abstract：
BACKGROUND: Rubber accelerators are used in the production of rubber gloves and may cause contact allergy.
OBJECTIVE: To estimate long-term trend and prevalence of contact allergy to rubber accelerators for a 30-year period in Denmark, high-risk occupations, and exposures.
METHODS: Data from all patients with contact dermatitis consecutively patch tested at the department of Skin and Allergy Gentofte hospital with the rubber accelerators from the European baseline series (EBS) from 1990 to 2019, were analysed. Further, patients under suspicion of rubber accelerator contact allergy were additionally patch-tested with rubber accelerators from the specialised rubber series from 2005 to 2019 and these were additional extracted.
RESULTS: The overall prevalence of contact allergy to one or more of the rubber accelerators from the EBS series was 2.7% with a significant decline in the first 12-years, followed by a stable frequency in the past 18-years. Associations with occupational contact dermatitis, hand dermatitis, and leg/foot dermatitis were found. Wet-work occupations were most often affected and gloves the most frequent exposure.
CONCLUSIONS: Contact allergy to one or more of the rubber accelerators from the EBS is frequent and has been unchanged for several decades, which calls for prevention.
OBJECTIVE: To estimate long-term trend and prevalence of contact allergy to rubber accelerators for a 30-year period in Denmark, high-risk occupations, and exposures.
METHODS: Data from all patients with contact dermatitis consecutively patch tested at the department of Skin and Allergy Gentofte hospital with the rubber accelerators from the European baseline series (EBS) from 1990 to 2019, were analysed. Further, patients under suspicion of rubber accelerator contact allergy were additionally patch-tested with rubber accelerators from the specialised rubber series from 2005 to 2019 and these were additional extracted.
RESULTS: The overall prevalence of contact allergy to one or more of the rubber accelerators from the EBS series was 2.7% with a significant decline in the first 12-years, followed by a stable frequency in the past 18-years. Associations with occupational contact dermatitis, hand dermatitis, and leg/foot dermatitis were found. Wet-work occupations were most often affected and gloves the most frequent exposure.
CONCLUSIONS: Contact allergy to one or more of the rubber accelerators from the EBS is frequent and has been unchanged for several decades, which calls for prevention.
摘要：
背景：橡胶促进剂用于橡胶手套的生产，可能会引起接触过敏。
目的：评估丹麦对橡胶促进剂接触过敏30年的长期趋势和患病率，高风险职业,和曝光。
方法：分析了1990年至2019年在皮肤和过敏Gentofte医院使用欧洲基线系列（EBS）的橡胶加速器连续贴片测试的所有接触性皮炎患者的数据。Further,从2005年至2019年,怀疑有橡胶促进剂接触过敏的患者还接受了来自专业橡胶系列的橡胶促进剂的斑贴试验,并对这些患者进行了额外提取.
结果：对来自EBS系列的一种或多种橡胶促进剂的接触过敏的总体患病率为2.7％，在最初的12年内显着下降，其次是过去18年的稳定频率。与职业性接触性皮炎有关，手部皮炎,发现了腿/足皮炎。湿工职业最常受到影响，手套最常暴露。
结论：对来自EBS的一种或多种橡胶促进剂的接触过敏是常见的，并且几十年来一直没有变化，这就需要预防。
目的：评估丹麦对橡胶促进剂接触过敏30年的长期趋势和患病率，高风险职业,和曝光。
方法：分析了1990年至2019年在皮肤和过敏Gentofte医院使用欧洲基线系列（EBS）的橡胶加速器连续贴片测试的所有接触性皮炎患者的数据。Further,从2005年至2019年,怀疑有橡胶促进剂接触过敏的患者还接受了来自专业橡胶系列的橡胶促进剂的斑贴试验,并对这些患者进行了额外提取.
结果：对来自EBS系列的一种或多种橡胶促进剂的接触过敏的总体患病率为2.7％，在最初的12年内显着下降，其次是过去18年的稳定频率。与职业性接触性皮炎有关，手部皮炎,发现了腿/足皮炎。湿工职业最常受到影响，手套最常暴露。
结论：对来自EBS的一种或多种橡胶促进剂的接触过敏是常见的，并且几十年来一直没有变化，这就需要预防。
