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Abstract：
Multiple myeloma (MM) is a hematologic malignancy characterized by the abnormal clonal proliferation of plasma cells that may result in focal bone lesions, renal failure, anemia, and/or hypercalcemia. Recently, the diagnosis and treatment of MM have evolved due to a better understanding of disease pathophysiology, improved risk stratification, and new treatments. The incorporation of new drugs, including proteasome inhibitors, immunomodulatory drugs, anti-CD38 antibodies and high-dose chemotherapy followed by hematopoietic stem cell transplantation, has resulted in a significant improvement in patient outcomes and QoL. In this review, we summarize differential diagnoses and therapeutic advances in MM.
摘要：
多发性骨髓瘤（MM）是一种血液系统恶性肿瘤，其特征是浆细胞的异常克隆增殖，可能导致局灶性骨病变。肾功能衰竭,贫血,和/或高钙血症。最近,由于对疾病病理生理学的更好理解，MM的诊断和治疗已经发展起来，改进风险分层，和新的治疗方法。合并新药，包括蛋白酶体抑制剂,免疫调节药物，抗CD38抗体和大剂量化疗，然后进行造血干细胞移植，已导致患者预后和QoL的显着改善。在这次审查中,我们总结了MM的鉴别诊断和治疗进展。
