Abstract：
Purpose: To analyze the effect of different feeding types on bronchopulmonary dysplasia (BPD) in very low birth weight preterm infants. Methods: The Cochrane Library, PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, China Biomedical Literature Database (CBM) were searched for literature related to breastfeeding and BPD, with a search period from their inception to January 2023. Two researchers independently screened the literature, extracted data, and assessed the quality of included studies before analyzing the data using Stata16 and RevMan5.4.1 software. Results: A total of 17 studies were included. The results showed that there was no significant difference in the frequency of BPD between human milk (HM) and donor human milk (DHM) (OR = 0.54, 95% CI: 0.29-1.03, p = 0.07). However, DHM had a significant effect in reducing the frequency of BPD compared to preterm formula (PF) (OR = 0.62, 95% CI: 0.41-0.94, p = 0.02). Exclusive HM also had a significant effect in reducing the frequency of BPD compared to exclusive PF (OR = 0.51, 95% CI: 0.34-0.78, p = 0.002), as well as compared to any PF (OR = 0.57, 95% CI: 0.37-0.88, p = 0.01). Furthermore, mainly (>50%) HM had a significant effect in reducing the frequency of BPD compared to mainly PF (OR = 0.72, 95% CI: 0.55-0.93, p = 0.01). However, there was no statistically significant difference between any HM and exclusive PF (OR = 0.88, 95% CI: 0.62-1.23, p = 0.46). Conclusions: Our study findings suggest that both HM and DHM have a significant protective effect in reducing the frequency of BPD occurrence compared to PF. Furthermore, even when the amount of HM is insufficient, feeding more than 50% of the HM volume still provides a protective effect against the frequency of BPD. Therefore, we recommend feeding infants with more than 50% of HM to harness the protective effect of HM against BPD occurrence.
摘要：
目的:分析不同喂养方式对极低出生体重早产儿支气管肺发育不良(BPD)的影响。方法：Cochrane图书馆，PubMed,Embase,中国国家知识基础设施(CNKI),万方数据知识服务平台,检索中国生物医学文献数据库（CBM）有关母乳喂养和BPD的文献，从成立到2023年1月的搜索期。两名研究人员独立筛选了文献，提取的数据，并在使用Stata16和RevMan5.4.1软件分析数据之前评估纳入研究的质量。结果：共纳入17项研究。结果表明，人乳（HM）和供体人乳（DHM）之间的BPD频率没有显着差异（OR=0.54，95％CI：0.29-1.03，p=0.07）。然而,与早产公式（PF）相比，DHM在降低BPD频率方面具有显着作用（OR=0.62，95％CI：0.41-0.94，p=0.02）。与排他性PF相比，排他性HM在降低BPD频率方面也具有显着效果（OR=0.51，95％CI：0.34-0.78，p=0.002），以及与任何PF相比（OR=0.57，95%CI：0.37-0.88，p=0.01）。此外，与主要PF相比，主要（>50％）HM在降低BPD频率方面具有显着效果（OR=0.72，95％CI：0.55-0.93，p=0.01）。然而,任何HM和排他性PF之间没有统计学上的显着差异（OR=0.88，95％CI：0.62-1.23，p=0.46）。结论：我们的研究结果表明，与PF相比，HM和DHM在降低BPD发生频率方面具有显着的保护作用。此外，即使HM的量不足，喂食超过50％的HM体积仍然对BPD的频率具有保护作用。因此,我们建议喂养超过50％HM的婴儿，以利用HM对BPD发生的保护作用。
