PDF(Pubmed)
Abstract：
Primary amebic meningoencephalitis (PAM) is a rare, but almost always fatal, central nervous system infection caused by Naegleria fowleri, which are thermophilic free-living amoeba. Here, we report the first case of PAM detected in South Korea, probably imported from Thailand. Despite antimicrobial treatment for N. fowleri infection with a combination of intravenous liposomal amphotericin B, fluconazole, azithromycin, and oral rifampin, the patient died 13 days after the onset of symptoms. Clinicians in South Korea treating severe meningoencephalitis, especially in individuals returning from tropical areas, are encouraged to include PAM in the differential diagnoses, given the accelerated global warming and increased overseas trips.
摘要：
原发性阿米巴脑膜脑炎（PAM）是一种罕见的，但几乎总是致命的，由福氏Naegleria引起的中枢神经系统感染，是嗜热的自由生活变形虫.这里,我们报告了在韩国发现的第一例PAM，可能是从泰国进口的。尽管用静脉内脂质体两性霉素B联合进行了抗微生物治疗。氟康唑,阿奇霉素,和口服利福平,患者在症状出现13天后死亡。韩国的临床医生治疗严重的脑膜脑炎,特别是从热带地区返回的人，鼓励将PAM纳入鉴别诊断中，考虑到全球变暖的加速和海外旅行的增加。
