PDF(Pubmed)
Abstract：
UNASSIGNED: To determine the common precipitating factors for breakthrough seizures in children with epilepsy.
UNASSIGNED: This retrospective study reviewed the charts of children with epilepsy who were followed up in the pediatric neurology clinic of King Fahad Hospital in Al-Baha region, Saudi Arabia, between January 2015 and August 2022. Children between 1 to 14 years of age who had epilepsy, as per the International League Against Epilepsy definition and received anti-seizure medication with a seizure-free period of at least 2 months before breakthrough seizure episode, were included in the study.
UNASSIGNED: Of the 108 children included in the study, the mean age was 6.8±1.6 years, and among them (55.5%) were male. Most parents (69.5%) were unaware of the triggering factors of seizure. The majority of patients (88%) reported at least one precipitating factor for breakthrough seizures and the most common one was systemic infection associated with fever (52.8%), and then non-compliance to medications in (34.3%) of the patients. In terms of the electroencephalogram, around 84 patients (77.8%) had abnormal electroencephalogram. Finally, monotherapy was maintained in 63.9% of patients.
UNASSIGNED: We conclude that the most common trigger for breakthrough seizure is a systemic infection associated with fever and non-compliance to anti-seizure medications. Increasing the level of awareness by different methods may help limit or even prevent seizures from occurring. Randomized controlled trials could shed light on the adjustment of anti-seizure medications temporarily by increasing the dosage or giving extra doses during the infection to avoid breakthrough seizures.
UNASSIGNED: This retrospective study reviewed the charts of children with epilepsy who were followed up in the pediatric neurology clinic of King Fahad Hospital in Al-Baha region, Saudi Arabia, between January 2015 and August 2022. Children between 1 to 14 years of age who had epilepsy, as per the International League Against Epilepsy definition and received anti-seizure medication with a seizure-free period of at least 2 months before breakthrough seizure episode, were included in the study.
UNASSIGNED: Of the 108 children included in the study, the mean age was 6.8±1.6 years, and among them (55.5%) were male. Most parents (69.5%) were unaware of the triggering factors of seizure. The majority of patients (88%) reported at least one precipitating factor for breakthrough seizures and the most common one was systemic infection associated with fever (52.8%), and then non-compliance to medications in (34.3%) of the patients. In terms of the electroencephalogram, around 84 patients (77.8%) had abnormal electroencephalogram. Finally, monotherapy was maintained in 63.9% of patients.
UNASSIGNED: We conclude that the most common trigger for breakthrough seizure is a systemic infection associated with fever and non-compliance to anti-seizure medications. Increasing the level of awareness by different methods may help limit or even prevent seizures from occurring. Randomized controlled trials could shed light on the adjustment of anti-seizure medications temporarily by increasing the dosage or giving extra doses during the infection to avoid breakthrough seizures.
摘要：
■确定癫痫儿童突破性发作的常见诱发因素。
这项回顾性研究回顾了在Al-Baha地区KingFahad医院儿科神经科门诊随访的癫痫患儿的图表，沙特阿拉伯,2015年1月至2022年8月。1至14岁的儿童患有癫痫，根据国际抗癫痫联盟的定义，并在突破性癫痫发作前至少2个月接受抗癫痫药物治疗，包括在研究中。
■在纳入研究的108名儿童中，平均年龄为6.8±1.6岁，其中(55.5%)为男性。大多数父母（69.5％）不知道癫痫发作的触发因素。大多数患者（88％）报告至少有一个突发性癫痫发作的诱发因素，最常见的是与发烧相关的全身性感染（52.8％）。然后（34.3％）的患者不遵守药物治疗。就脑电图而言，约84例(77.8%)患者脑电图异常。最后,单药治疗维持在63.9%的患者中.
■我们得出的结论是，突破性癫痫发作最常见的诱因是与发烧和不遵守抗癫痫药物有关的全身性感染。通过不同的方法提高意识水平可能有助于限制甚至预防癫痫发作的发生。随机对照试验可以通过增加剂量或在感染期间给予额外剂量以避免突破性癫痫发作来暂时调整抗癫痫药物。
这项回顾性研究回顾了在Al-Baha地区KingFahad医院儿科神经科门诊随访的癫痫患儿的图表，沙特阿拉伯,2015年1月至2022年8月。1至14岁的儿童患有癫痫，根据国际抗癫痫联盟的定义，并在突破性癫痫发作前至少2个月接受抗癫痫药物治疗，包括在研究中。
■在纳入研究的108名儿童中，平均年龄为6.8±1.6岁，其中(55.5%)为男性。大多数父母（69.5％）不知道癫痫发作的触发因素。大多数患者（88％）报告至少有一个突发性癫痫发作的诱发因素，最常见的是与发烧相关的全身性感染（52.8％）。然后（34.3％）的患者不遵守药物治疗。就脑电图而言，约84例(77.8%)患者脑电图异常。最后,单药治疗维持在63.9%的患者中.
■我们得出的结论是，突破性癫痫发作最常见的诱因是与发烧和不遵守抗癫痫药物有关的全身性感染。通过不同的方法提高意识水平可能有助于限制甚至预防癫痫发作的发生。随机对照试验可以通过增加剂量或在感染期间给予额外剂量以避免突破性癫痫发作来暂时调整抗癫痫药物。
