%0 Journal Article
%T The Frequency and Precipitating Factors for Breakthrough Seizures in Children with Epilepsy.
%A Aldosari AN
%A Alghamdi A
%A Alharthi A
%A Albuhayri A
%A Ghurab S
%A Alghamdi M
%A Aldosari M
%J J Epilepsy Res
%V 13
%N 1
%D 2023 Jun 30
%M 37720680
暂无%R 10.14581/jer.23003
%X <B>UNASSIGNED: </B>To determine the common precipitating factors for breakthrough seizures in children with epilepsy.<BR><B>UNASSIGNED: </B>This retrospective study reviewed the charts of children with epilepsy who were followed up in the pediatric neurology clinic of King Fahad Hospital in Al-Baha region, Saudi Arabia, between January 2015 and August 2022. Children between 1 to 14 years of age who had epilepsy, as per the International League Against Epilepsy definition and received anti-seizure medication with a seizure-free period of at least 2 months before breakthrough seizure episode, were included in the study.<BR><B>UNASSIGNED: </B>Of the 108 children included in the study, the mean age was 6.8±1.6 years, and among them (55.5%) were male. Most parents (69.5%) were unaware of the triggering factors of seizure. The majority of patients (88%) reported at least one precipitating factor for breakthrough seizures and the most common one was systemic infection associated with fever (52.8%), and then non-compliance to medications in (34.3%) of the patients. In terms of the electroencephalogram, around 84 patients (77.8%) had abnormal electroencephalogram. Finally, monotherapy was maintained in 63.9% of patients.<BR><B>UNASSIGNED: </B>We conclude that the most common trigger for breakthrough seizure is a systemic infection associated with fever and non-compliance to anti-seizure medications. Increasing the level of awareness by different methods may help limit or even prevent seizures from occurring. Randomized controlled trials could shed light on the adjustment of anti-seizure medications temporarily by increasing the dosage or giving extra doses during the infection to avoid breakthrough seizures.