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Abstract：
Introduction: Bone metastasis is one of the causes that mainly decrease survival in patients with advanced breast cancer. Therefore, it is essential to find prognostic markers for the occurrence of this type of metastasis during the early stage of the disease. Currently, cancer-associated fibroblasts, which represent 80% of the fibroblasts present in the tumor microenvironment, are an interesting target for studying new biomarkers and developing alternative therapies. This study evaluated the prognostic significance of the CD105 expression in cancer-associated fibroblasts in early breast cancer patients. Methods: Immunohistochemistry was used to assess CD105 expression in invasive ductal breast carcinomas (n = 342), analyzing its association with clinical and pathological characteristics. Results: High CD105 expression in cancer-associated fibroblasts was associated with an increased risk of metastatic occurrence (p = 0.0003), particularly bone metastasis (p = 0.0005). Furthermore, high CD105 expression was associated with shorter metastasis-free survival, bone metastasis-free survival, and overall survival (p = 0.0002, 0.0006, and 0.0002, respectively). CD105 expression also constituted an independent prognostic factor for metastasis-free survival, bone metastasis-free survival, and overall survival (p = 0.0003, 0.0006, and 0.0001, respectively). Discussion: The high CD105 expression in cancer-associated fibroblasts is an independent prognostic marker for bone metastasis in early breast cancer patients. Therefore, the evaluation of CD105(+) CAFs could be crucial to stratify BCPs based on their individual risk profile for the development of BM, enhancing treatment strategies and outcomes.
摘要：
简介：骨转移是导致晚期乳腺癌患者生存率下降的主要原因之一。因此,在疾病的早期阶段，找到这种类型的转移发生的预后标志物是至关重要的。目前,癌症相关成纤维细胞，它们代表了肿瘤微环境中80%的成纤维细胞，是研究新生物标志物和开发替代疗法的有趣目标。这项研究评估了早期乳腺癌患者癌症相关成纤维细胞中CD105表达的预后意义。方法：采用免疫组织化学方法评估浸润性导管癌（n=342）中CD105的表达，分析其与临床病理特征的关系。结果：CD105在癌症相关成纤维细胞中的高表达与转移发生的风险增加相关（p=0.0003）。特别是骨转移（p=0.0005）。此外，高CD105表达与较短的无转移生存期相关,无骨转移生存率，和总生存期(分别为p=0.0002,0.0006和0.0002)。CD105表达也是无转移生存的独立预后因素，无骨转移生存率，和总生存期(分别为p=0.0003,0.0006和0.0001)。讨论：CD105在癌症相关成纤维细胞中的高表达是早期乳腺癌患者骨转移的独立预后标志物。因此,CD105(+)CAF的评估对于根据BCP的个体风险状况对BM的发展进行分层至关重要，加强治疗策略和结果。
