PDF(Pubmed)
Abstract：
BACKGROUND: Acrometastasis is an uncommon finding in non-small cell lung cancer and is usually a sign of multimetastatic disease. Few case reports have suggested solitary digital metastasis as the single secondary lesion of oligometastatic non-small cell lung cancer.
METHODS: This case report describes an unusual presentation of a Kirsten rat sarcoma viral oncogene homolog-mutated lung adenocarcinoma with a solitary bone metastasis in the fourth finger medial phalanx, which was also the first sign of the disease, in a 63-year-old Caucasian female patient. Digital surgical amputation was performed. After histopathological confirmation and radiological exclusion of other secondary lesions, chemoimmunotherapy in a first-line setting was initiated. A partial metabolic response in the primary lung lesion was observed after four cycles. Maintenance therapy is currently being continued.
CONCLUSIONS: Solitary digital metastasis is a rare finding in non-small cell lung cancer. Further studies are needed to investigate the mechanisms behind this particular dissemination process.
METHODS: This case report describes an unusual presentation of a Kirsten rat sarcoma viral oncogene homolog-mutated lung adenocarcinoma with a solitary bone metastasis in the fourth finger medial phalanx, which was also the first sign of the disease, in a 63-year-old Caucasian female patient. Digital surgical amputation was performed. After histopathological confirmation and radiological exclusion of other secondary lesions, chemoimmunotherapy in a first-line setting was initiated. A partial metabolic response in the primary lung lesion was observed after four cycles. Maintenance therapy is currently being continued.
CONCLUSIONS: Solitary digital metastasis is a rare finding in non-small cell lung cancer. Further studies are needed to investigate the mechanisms behind this particular dissemination process.
摘要：
背景：在非小细胞肺癌中，侵袭转移是一种罕见的发现，通常是多表现疾病的征兆。很少有病例报告表明，孤立的数字转移是寡转移非小细胞肺癌的单个继发性病变。
方法：本病例报告描述了Kirsten大鼠肉瘤病毒癌基因同源突变的肺腺癌的不寻常表现，在第四指内侧指骨中存在孤立性骨转移，这也是这种疾病的第一个迹象，一名63岁的白人女性患者。进行数字手术截肢。在组织病理学确认和放射学排除其他继发性病变后，在一线环境中开始了化学免疫疗法。四个周期后观察到原发性肺病变的部分代谢反应。目前正在继续维持治疗。
结论：孤立性数字化转移在非小细胞肺癌中是一种罕见的发现。需要进一步的研究来调查这一特定传播过程背后的机制。
方法：本病例报告描述了Kirsten大鼠肉瘤病毒癌基因同源突变的肺腺癌的不寻常表现，在第四指内侧指骨中存在孤立性骨转移，这也是这种疾病的第一个迹象，一名63岁的白人女性患者。进行数字手术截肢。在组织病理学确认和放射学排除其他继发性病变后，在一线环境中开始了化学免疫疗法。四个周期后观察到原发性肺病变的部分代谢反应。目前正在继续维持治疗。
结论：孤立性数字化转移在非小细胞肺癌中是一种罕见的发现。需要进一步的研究来调查这一特定传播过程背后的机制。
