Abstract：
Outcomes for chronic myelomonocytic leukemia (CMML) are insufficiently characterized at the population level. We analyzed epidemiological trends for patients between 2001 and 2017, focusing on age, sex, race, and long-term survivors. Using the Surveillance, Epidemiology, and End Results Program, we studied 3929 patients, in four time-period (tp) cohorts, based on year of diagnosis [2001-2004 (tp1); 2005-2009 (tp2); 2010-2013 (tp3); 2014-2017 (tp4)]. Stable incidence overall, male predominance, and higher incidence for White versus Black and \'Other\' races were noted. Three-year relative survival (RS) increased from 27.9% to 36.9% between tp1 and tp4. The most pronounced increase occurred between tp1 and tp2. All subgroups generally experienced RS improvements over time, except notably Black patients. Improvements for patients aged 85+ (3-year RS 8.4-23.6% between tp1 and tp4) and increases in long-term survivors (5-year OS from 13.2-22.3%) were observed. Additional study is warranted to explore these associations, particularly for Black patients.
摘要：
慢性粒单核细胞白血病（CMML）的结果在人群水平上没有得到充分表征。我们分析了2001年至2017年患者的流行病学趋势，重点是年龄，性别,种族,和长期幸存者。利用监控，流行病学,和最终结果计划，我们研究了3929名患者,在四个时间段(TP)队列中，根据诊断年份[2001-2004（tp1）;2005-2009（tp2）;2010-2013（tp3）;2014-2017（tp4）]。总体发病率稳定，男性占主导地位，注意到白人与黑人和“其他种族”的发病率更高。在tp1和tp4之间，三年相对生存率（RS）从27.9%增加到36.9%。最明显的增加发生在tp1和tp2之间。随着时间的推移，所有亚组通常都经历了RS改善，除了黑人患者。观察到85岁以上患者的改善（tp1和tp4之间的3年RS8.4-23.6％）和长期幸存者的增加（5年OS从13.2-22.3％）。需要额外的研究来探索这些关联，特别是黑人患者。
