Abstract：
Follicular fluid (FF) advanced glycation end products (AGEs) have been associated with low oocyte quality and number, low fertilization rate, impaired embryonic development and low pregnancy rate. These findings are especially relevant in women undergoing in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), ie, assisted reproductive technology (ART). A systematic literature search was conducted to examine various AGEs including pentosidine, carboxymethyl-lysine (CML), methylglyoxal 5-hydro-5-methylimidazolones (MG-H1), toxic AGE (TAGE), and soluble receptor for AGE (sRAGE) with ART outcomes. Studies showed that total AGEs and sRAGE in FF were associated with the ovarian response, follicle number, retrieved oocyte number, mature (MII) oocyte number, fertilization rate, embryo number, embryo quality, and successful pregnancy. Although FF AGEs could be considered predictive biomarkers, population heterogeneity and differences in ovulation induction protocols make the findings less clear. This review highlights important role of AGEs in ART and necessity of evaluating AGEs in serum vs with FF to better predict ART outcomes.
摘要：
卵泡液（FF）晚期糖基化终产物（AGEs）与低卵母细胞质量和数量有关，低施肥率,胚胎发育受损，妊娠率低。这些发现在接受体外受精（IVF）和卵胞浆内单精子注射（ICSI）的妇女中尤其重要。ie,辅助生殖技术（ART）。进行了系统的文献检索，以检查各种AGEs，包括戊糖苷，羧甲基赖氨酸（CML），甲基乙二醛5-氢-5-甲基咪唑酮（MG-H1），有毒年龄（TAGE），和可溶性AGE受体（sRAGE）与ART结果。研究表明，FF中的总AGEs和sRAGE与卵巢反应有关，卵泡数,检索到的卵母细胞数量，成熟（MII）卵母细胞数，受精率,胚胎数量,胚胎质量,成功怀孕。尽管FFAGEs可以被认为是预测性生物标志物，群体异质性和排卵诱导方案的差异使研究结果不太清楚.这篇综述强调了AGEs在ART中的重要作用以及评估血清与FF中AGEs以更好地预测ART结果的必要性。
