PDF(Pubmed)
Abstract：
OBJECTIVE: To assess factors associated with long-term neuropsychiatric outcomes, including biomarkers measured after discharge from the intensive care unit.
METHODS: A prospective cohort study was performed with 65 intensive care unit survivors. The cognitive evaluation was performed through the Mini-Mental State Examination, the symptoms of anxiety and depression were evaluated using the Hospital Anxiety and Depression Scale, and posttraumatic stress disorder was evaluated using the Impact of Event Scale-6. Plasma levels of amyloid-beta (1-42) [Aβ (1-42)], Aβ (1-40), interleukin (IL)-10, IL-6, IL-33, IL-4, IL-5, tumor necrosis factor alpha, C-reactive protein, and brain-derived neurotrophic factor were measured at intensive care unit discharge.
RESULTS: Of the variables associated with intensive care, only delirium was independently related to the occurrence of long-term cognitive impairment. In addition, higher levels of IL-10 and IL-6 were associated with cognitive dysfunction. Only IL-6 was independently associated with depression. Mechanical ventilation, IL-33 levels, and C-reactive protein levels were independently associated with anxiety. No variables were independently associated with posttraumatic stress disorder.
CONCLUSIONS: Cognitive dysfunction, as well as symptoms of depression, anxiety, and posttraumatic stress disorder, are present in patients who survive a critical illness, and some of these outcomes are associated with the levels of inflammatory biomarkers measured at discharge from the intensive care unit.
METHODS: A prospective cohort study was performed with 65 intensive care unit survivors. The cognitive evaluation was performed through the Mini-Mental State Examination, the symptoms of anxiety and depression were evaluated using the Hospital Anxiety and Depression Scale, and posttraumatic stress disorder was evaluated using the Impact of Event Scale-6. Plasma levels of amyloid-beta (1-42) [Aβ (1-42)], Aβ (1-40), interleukin (IL)-10, IL-6, IL-33, IL-4, IL-5, tumor necrosis factor alpha, C-reactive protein, and brain-derived neurotrophic factor were measured at intensive care unit discharge.
RESULTS: Of the variables associated with intensive care, only delirium was independently related to the occurrence of long-term cognitive impairment. In addition, higher levels of IL-10 and IL-6 were associated with cognitive dysfunction. Only IL-6 was independently associated with depression. Mechanical ventilation, IL-33 levels, and C-reactive protein levels were independently associated with anxiety. No variables were independently associated with posttraumatic stress disorder.
CONCLUSIONS: Cognitive dysfunction, as well as symptoms of depression, anxiety, and posttraumatic stress disorder, are present in patients who survive a critical illness, and some of these outcomes are associated with the levels of inflammatory biomarkers measured at discharge from the intensive care unit.
摘要：
目的：评估与长期神经精神预后相关的因素，包括从重症监护病房出院后测量的生物标志物。
方法：对65名重症监护病房幸存者进行了一项前瞻性队列研究。认知评估是通过迷你精神状态检查进行的，采用医院焦虑抑郁量表对患者的焦虑和抑郁症状进行评估,创伤后应激障碍使用事件影响量表-6进行评估。β淀粉样蛋白（1-42）[Aβ（1-42）]的血浆水平，Aβ(1-40),白细胞介素（IL）-10，IL-6，IL-33，IL-4，IL-5，肿瘤坏死因子α，C反应蛋白,在重症监护病房出院时测量脑源性神经营养因子。
结果：在与重症监护相关的变量中，只有谵妄与长期认知障碍的发生独立相关。此外,IL-10和IL-6水平升高与认知功能障碍相关.只有IL-6与抑郁症独立相关。机械通气,IL-33水平,C反应蛋白水平与焦虑独立相关。没有变量与创伤后应激障碍独立相关。
结论：认知功能障碍，以及抑郁症的症状，焦虑,和创伤后应激障碍，存在于重症患者中，其中一些结局与重症监护病房出院时测得的炎性生物标志物水平相关.
方法：对65名重症监护病房幸存者进行了一项前瞻性队列研究。认知评估是通过迷你精神状态检查进行的，采用医院焦虑抑郁量表对患者的焦虑和抑郁症状进行评估,创伤后应激障碍使用事件影响量表-6进行评估。β淀粉样蛋白（1-42）[Aβ（1-42）]的血浆水平，Aβ(1-40),白细胞介素（IL）-10，IL-6，IL-33，IL-4，IL-5，肿瘤坏死因子α，C反应蛋白,在重症监护病房出院时测量脑源性神经营养因子。
结果：在与重症监护相关的变量中，只有谵妄与长期认知障碍的发生独立相关。此外,IL-10和IL-6水平升高与认知功能障碍相关.只有IL-6与抑郁症独立相关。机械通气,IL-33水平,C反应蛋白水平与焦虑独立相关。没有变量与创伤后应激障碍独立相关。
结论：认知功能障碍，以及抑郁症的症状，焦虑,和创伤后应激障碍，存在于重症患者中，其中一些结局与重症监护病房出院时测得的炎性生物标志物水平相关.
